JAK2-IN-5
JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC50 of 0.078 μM against JAK-2 and an IC50 of 0.206 μM against JAK-2V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.
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- No. CAS: 1110502-30-1
- Fòrmula: C17H20N4O2S
- Peso molecular:344.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
JAK2 0.078 μM (IC50) |
JAK2V617F 0.206 μM (IC50) |
In Vitro
JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC50 of 78 nM and a ligand efficiency of 0.41 kcal mol-1[1].
JAK2-IN-5 inhibits JAK-2V617F mutant kinase with an IC50 of 206 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 1110502-30-1
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Peso molecular 344.43
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Fòrmula C17H20N4O2S
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SMILES
O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-5 Related Classifications
HY-136734 Related Classifications
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