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53 Results for "

Urease Inhibitor

" in MedChemExpress (MCE) Product Catalog:

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Pedalitin

2 Cited Publications

Cat. No.: HY-N3101

CAS No.: 22384-63-0

Category:

Flavonoids Flavones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Endocrinology

Target:

Endogenous Metabolite Tyrosinase Glycosidase Xanthine Oxidase Glutathione Peroxidase Fungal

Pedalitin is a tyrosinase and α-glucosidase inhibitor with IC₅₀ values of 0.28 mM and 0.29 mM, respectively, and can be isolated and extracted from Rabdosia serra. Pedalitin is a xanthine oxidase (Xanthine Oxidase) (IC₅₀ = 3.7 µM) and myeloperoxidase (MPO) (IC₅₀ = 3.8 nM) inhibitor. Pedalitin ameliorates NAFLD by downregulating the EGFR/IRS1/AKT1/FOXO1 signaling pathway and related inflammatory and lipid metabolism factors. Pedalitin reduces the risk of urinary tract infection and stones by inhibiting the expression of the urease UreC gene in Proteus mirabilis. Pedalitin also exhibits antifungal activity, with a MIC of 3.9 mg/L against Cryptococcus neoformans. Pedalitin can be used for research on non-alcoholic fatty liver disease, chronic kidney disease, kidney stones, cryptococcosis, and abdominal pain .

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Acetohydroxamic acid

1 Cited Publications

Cat. No.: HY-B1235

CAS No.: 546-88-3

Synonyms: N-Hydroxyacetamide

Target:

Free Radical Scavengers Bacterial HIV

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .

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