22384-63-0
Chemical Structure
Pedalitin
- CAS No.: 22384-63-0
- Formula:C16H12O7
- Molecular Weight:316.26
IUPAC Name: 2-(3,4-dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-chromen-4-one
InChIKey: QWUHUBDKQQPMQG-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(OC)=C(O)C(O)=C13
Biological Activity: Pedalitin is a tyrosinase and α-glucosidase inhibitor with IC50 values of 0.28 mM and 0.29 mM, respectively, and can be isolated and extracted from Rabdosia serra. Pedalitin is a xanthine oxidase (Xanthine Oxidase) (IC50 = 3.7 µM) and myeloperoxidase (MPO) (IC50 = 3.8 nM) inhibitor. Pedalitin ameliorates NAFLD by downregulating the EGFR/IRS1/AKT1/FOXO1 signaling pathway and related inflammatory and lipid metabolism factors. Pedalitin reduces the risk of urinary tract infection and stones by inhibiting the expression of the urease UreC gene in Proteus mirabilis. Pedalitin also exhibits antifungal activity, with a MIC of 3.9 mg/L against Cryptococcus neoformans. Pedalitin can be used for research on non-alcoholic fatty liver disease, chronic kidney disease, kidney stones, cryptococcosis, and abdominal pain[1][2][3][4][5][6][7][8][9][10][11].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pedalitin | 99.67% | Pedalitin is a tyrosinase and α-glucosidase inhibitor with IC50 values of 0.28 mM and 0.29 mM, respectively, and can be isolated and extracted from Rabdosia serra. Pedalitin is a xanthine oxidase (Xanthine Oxidase) (IC50 = 3.7 µM) and myeloperoxidase (MPO) (IC50 = 3.8 nM) inhibitor. Pedalitin ameliorates NAFLD by downregulating the EGFR/IRS1/AKT1/FOXO1 signaling pathway and related inflammatory and lipid metabolism factors. Pedalitin reduces the risk of urinary tract infection and stones by inhibiting the expression of the urease UreC gene in Proteus mirabilis. Pedalitin also exhibits antifungal activity, with a MIC of 3.9 mg/L against Cryptococcus neoformans. Pedalitin can be used for research on non-alcoholic fatty liver disease, chronic kidney disease, kidney stones, cryptococcosis, and abdominal pain. | ||||||||||||||||||||
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References
- [1]. He W, et al. Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model. J Holist Integr Pharm. 2024;5(4):314-322.
- [2]. Ramarao V. Polyphenolic-Enriched Fraction from Pedalium murex Roots Mitigates Renal Fibrosis: Integrated Phytochemical, et al.
- [3]. Fernandes DC, et al. Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. Chemical & pharmaceutical bulletin. 2008 May;56(5):723-6. [Content Brief]
- [4]. Yamamoto S, et al. Arachidonate 5-lipoxygenase and its new inhibitors. J Allergy Clin Immunol. 1984;74(3 Pt 2):349-352.
- [5]. Ramadevi S, et al. Effect of traditionally used herb L. and its active compound pedalitin on urease expression - For the management of kidney stone. Saudi journal of biological sciences. 2020 Mar;27(3):833-839.
- [6]. Moharram FA, et al. Polyphenolic profile and biological activity of Salvia splendens leaves. The Journal of pharmacy and pharmacology. 2012 Nov;64(11):1678-87.
- [7]. Piatek M, et al. Galleria mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions. Antibiotics. 2021;10(12):1545.
- [8]. Piatek M, et al. Utilising Galleria mellonella larvae for studying in vivo activity of conventional and novel antimicrobial agents. Pathog Dis. 2020;78(8):ftaa059.
- [9]. Moreno-Pérez GF, et al. Amarisolide A and Pedalitin as Bioactive Compounds in the Antinociceptive Effects of Salvia circinata (Lamiaceae). Bot Sci. 2019;97(3):355-365.
- [10]. Sangalli-Leite F, et al. Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation. International journal of antimicrobial agents. 2016 Nov;48(5):504-511.
- [11]. Lin L, et al. Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase. Food Chem. 2011 Dec 1;129(3):884-9. [Content Brief]
