78 Results for "

depolymerization

" in MedChemExpress (MCE) Product Catalog:
Products (78)

78 Results for "depolymerization" in MCE Product Catalog:

183
Docetaxel
Docetaxel
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183 Publications Verification
Cat. No.: HY-B0011
CAS No.: 114977-28-5
Synonyms: RP-56976
Category:  

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .
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183
Docetaxel Trihydrate
Docetaxel Trihydrate
0 Images
183 Publications Verification
Cat. No.: HY-B0011A
CAS No.: 148408-66-6
Synonyms: RP-56976 Trihydrate
Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:  

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .
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111
Cytochalasin D
Cytochalasin D
0 Images
111 Cited Publications
Cat. No.: HY-N6682
CAS No.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Exosomes Arp2/3 Complex Antibiotic YAP

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
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21
Hyaluronidase, Bovine testes
Hyaluronidase, Bovine testes
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21 Cited Publications
Cat. No.: HY-107910
CAS No.: 37326-33-3
Synonyms: Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology Cancer

Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .
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4
7-epi-Taxol
7-epi-Taxol
0 Images
4 Cited Publications
Cat. No.: HY-N0227
CAS No.: 105454-04-4
Synonyms: 7-epi-Paclitaxel
Category:  

Taxaceae Extract Terpenoids Diterpenoids Plants Disease Research Fields Cancer 500 - Internal Server Error | MedChemExpress

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