2'-Nitroflavone
2'-Nitroflavone is a PARP1 inhibitor. 2'-Nitroflavone inhibits the proliferation, induces cell cycle arrest and apoptosis of triple-negative breast cancer cells. 2'-Nitroflavone also inhibits the migration of triple-negative breast cancer cells and endothelial cells. 2'-Nitroflavone exhibits antitumor activity and can be used in the research of tumors such as triple-negative breast cancer.
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- No. CAS: 53277-26-2
- Fòrmula: C15H9NO4
- Peso molecular:267.24
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Almacenamiento:
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PARP1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| WISH | IC50 |
3 μM
Compound: 14
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In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined
In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined
|
[PMID: 14684314] |
In Vitro
2'-Nitroflavone (1.25-40 μM; 0-96 h) inhibits the viability of three triple-negative breast cancer (TNBC) cell lines, MDA-MB-231, BT-549 and MDA-MB-468, with IC50 values of 4.0 μM, 9.2 μM and 6.5 μM after 72 h of treatment, respectively and has IC50 against EA.hy926 endothelial cells of 14.5 μM at 96 h[1].
2'-Nitroflavone (0-25 μM; 72-144 h) inhibits colony formation and migration of triple-negative breast cancer cells, and induces cell cycle arrest and apoptosis[1].
2'-Nitroflavone (1-25 μM; 72 h) reduces the protein level of α-tubulin in MDA-MB-231 and BT-549 cells, disrupts the arrangement of α-tubulin in cells, and induces the formation of multipolar mitotic spindles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:5 μM
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Incubation Time:72 h
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Result:Induced S and G2/M arrest in MDA-MB-231 cells.
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Cell Line:MDA-MB-231
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Concentration:1, 5, 25 μM
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Incubation Time:72 h
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Result:Significantly decreased viable cells and increased the percentage of early apoptotic cells at 25 μM compared to vehicle.
Significantly increased the percentage of hypodiploid cells at 5 and 25 μM compared to vehicle.
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Cell Line:MDA-MB-231, BT-549
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Concentration:1, 5, 25 μM
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Incubation Time:72 h
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Result:Significantly decreased α-tubulin protein expression in both cell lines at 25 μM.
Did not affect actin protein levels at any concentration tested.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 6-8 weeks old, 20-25 g, orthotopic syngeneic 4T1 cell model)[1]
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Dosage:20 mg/kg
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Administration:i.p.; daily 5 times per week; 2 weeks
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Result:Significantly decreased relative tumor volume compared to vehicle controls.
Had significant differences in body, liver, spleen, heart, or kidney weight between groups.
Chemical Information
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No. CAS 53277-26-2
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Peso molecular 267.24
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Fòrmula C15H9NO4
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SMILES
O=C1C2=CC=CC=C2OC(C3=C([N+]([O-])=O)C=CC=C3)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2'-Nitroflavone Related Classifications
HY-181068 Related Classifications
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