Nucleocidin
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.
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- No. CAS: 24751-69-7
- Fòrmula: C10H13FN6O6S
- Peso molecular:364.31
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
Antibacterial[1].
In Vitro
Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 24751-69-7
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Peso molecular 364.31
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Fòrmula C10H13FN6O6S
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SMILES
O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@@]3(F)COS(=O)(N)=O
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Synonyms
4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007
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Structure Classification
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Initial Source
Streptomyces calvus
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nucleocidin Related Classifications
HY-100496 Related Classifications
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