Tangeretin
Based on 16 publication(s) in Google Scholar
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.36%
- No. CAS: 481-53-8
- Fòrmula: C20H20O7
- Peso molecular:372.37
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-N0155
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HY-13027
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HY-N0168
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HY-N0019
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HY-N0101
NeohesperidinWnt/β-Catenin Activator -
HY-N1201
ApigeninCytochrome P450 Inhibitor -
HY-N0804
NarirutinShikimate Kinase Inhibitor
Publications Citing Use of MedChemExpress (MCE) Tangeretin
More- Phytomedicine. 2025 Sep:145:157034. [Abstract]
- Phytomedicine. 2024 Jan:123:154928. [Abstract]
- Phytomedicine. 2022 Apr:98:153928. [Abstract]
- Food Chem. 2025 Dec 30:497:146992. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- J Agric Food Chem. 2022 Sep 14;70(36):11236-11244. [Abstract]
- J Agric Food Chem. 2022 Feb 9;70(5):1536-1546. [Abstract]
- Ind Crops Prod. 2026 May 8;246:123392.
- Ind Crops Prod. 2025 Dec 11;239:122458.
- Eur J Pharmacol. 2025 Sep 15:1003:177994. [Abstract]
- Microb Pathog. 2020 Jan:138:103826. [Abstract]
- Am J Cancer Res. 2023 Nov 15;13(11):5254-5270. [Abstract]
- Biochem Biophys Res Commun. 2022 Nov 19:630:16-23. [Abstract]
- Rev Bras Farmacogn. 26 July 2022.
- Research Square Preprint. 2021 Oct.
- Biomed Pharmacother. 2020 Sep:129:110369. [Abstract]
Customer Validation & Images
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Histological Imaging/Staining
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IHC
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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WB
Actividad biológica
Descripciòn
IC50 & Target
Notch-1
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| 3T3-L1 | IC50 |
48 μM
Compound: 2, Tangeritin
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Anticorpulence activity against mouse 3T3L1 cells assessed as inhibition of lipid droplet accumulation
Anticorpulence activity against mouse 3T3L1 cells assessed as inhibition of lipid droplet accumulation
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[PMID: 19054677] |
| A2780 ADR | IC50 |
19 μM
Compound: 18
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Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay
Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay
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[PMID: 21354800] |
| HL-60 | IC50 |
>100 μM
Compound: IX
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Antiproliferative activity against HL60 after 24 hrs
Antiproliferative activity against HL60 after 24 hrs
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[PMID: 17391969] |
| HL-60 | IC50 |
10 ng/mL
Compound: Tangeretin
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Growth inhibition of human HL60 cells after 72 hrs by MTT assay
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
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[PMID: 31398616] |
| HT-29 | IC50 |
77 μM
Compound: 2, Tangeritin
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Anticancer activity against human HT-29 cells after 72 hrs by MTT assay
Anticancer activity against human HT-29 cells after 72 hrs by MTT assay
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[PMID: 19054677] |
| KB | ED50 |
15 μg/mL
Compound: NSC-53909
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 469554] |
| MCF7 | IC50 |
17 μM
Compound: 18
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Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
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[PMID: 21354800] |
| MDCK | IC50 |
19 μM
Compound: 18
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Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
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[PMID: 21354800] |
| MDCK | IC50 |
39 μM
Compound: 18
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Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry
Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry
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[PMID: 21354800] |
| Monocyte | IC50 |
30 μM
Compound: Tangeretin
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Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
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[PMID: 10096854] |
| RBL-2H3 | IC50 |
>500 μM
Compound: 7
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Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
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[PMID: 14510616] |
| SH-SY5Y | IC50 |
41.2 μM
Compound: TAN, tangeretin
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Growth inhibition of human SHSY5Y cells assessed as viable cells after 48 hrs by Trypan blue dye exclusion test
Growth inhibition of human SHSY5Y cells assessed as viable cells after 48 hrs by Trypan blue dye exclusion test
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[PMID: 18282757] |
In Vitro
Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 481-53-8
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Appearance Solid
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Peso molecular 372.37
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Fòrmula C20H20O7
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Color Off-white to yellow
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SMILES
O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
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Synonyms
Tangeritin; NSC53909; NSC618905
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (16)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury. [Abstract]2025 Sep:145:157034. PMID: 40617054
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157034. [Abstract]
Representative image of H&E-stained liver sections, scale bar: 200 μm. I/R-induced centrilobular necrosis was indicated by the dotted line. The results indicated a significant decrease in hepatic necrotic areas in Tangeretin (TAN, 10-40 mg/kg; i.p.; single dose) treated mice compared to the control group receiving nothing.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157034. [Abstract]
Representative pictures of liver stained with Ly-6 G (neutrophils) and F4/80 (macrophages), scale bar, 100 μm. Immunohistochemical analysis revealed significant decrease in hepatic inflammation in Tangeretin (TAN, 10-40 mg/kg; i.p.; single dose)-treated mice, and the infiltration of Ly6G+ neutrophils and F4/80+ macrophages was significantly decreased in TAN-treated mice livers compared to untreated mice.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157034. [Abstract]
Hepatocytes were treated with or without the treatment of Tangeretin (TAN) (25 μM) in the presence or absence of OGD/R-treatment for 6 h. At the end of experiment, Mitotracker (Green) and Lysotracker (Red) were co-stained, scale bars: 20 μm. The results showed that TAN treatment led to an enhanced colocalization of the mitochondrial probe Mitotracker with the lysosomal probe Lysotracker.
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Phytomedicine
Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling. [Abstract]2024 Jan:123:154928. PMID: 38043386 -
Phytomedicine
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways. [Abstract]2022 Apr:98:153928. PMID: 35104760
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Apr:98:153928. [Abstract]
Results of CCK-8 assay showing the effects of different Tangeretin concentrations (0, 5, 10, 20, 40, and 80 μM for 24 h) on the viability of chondrocytes.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Apr:98:153928. [Abstract]
Chondrocytes were treated with IL-1β (10 ng/ml) in the presence or absence of Tangeretin (5, 10, 20 μM) for 24 h. The protective effects of Tangeretin were examined by quantifying expression of collagen II, aggrecan, ADAMTS5, and MMP-13.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Apr:98:153928. [Abstract]
Immunofluorescence staining analysis of MMP13 and collagen II in chondrocytes treated with IL-1β (10 ng/ml) in the presence or absence Tangeretin (20 μM) for 24 h. Scale bar: 30 μm.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Apr:98:153928. [Abstract]
The chondrocytes were seeded in the culture dish for 24 h and then exposed to IL-1β (10 ng/ml) with or without Tangeretin (5, 10, 20 μM) for additional 24 h. Real-time PCR for the effects of Tangeretin on mRNAs levels of IL-6, TNF-α, iNOS and COX-2 in chondrocytes. The expression levels of these genes were normalized to the expression of β-actin.
Tangeretin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Apr:98:153928. [Abstract]
The chondrocytes were seeded in the culture dish for 24 h and then exposed to IL-1β (10 ng/ml) with or without Tangeretin (5, 10, 20 μM) for additional 24 h. ELISA or Griess reagent test for the effects of Tangeretin on PGE2, IL-6, TNF-α, and NO levels in the cell culture supernatants after indicated treatment.
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
J Agric Food Chem
Tangeretin Protects Mice from Alcohol-Induced Fatty Liver by Activating Mitophagy through the AMPK-ULK1 Pathway. [Abstract]2022 Sep 14;70(36):11236-11244. PMID: 36063077 -
J Agric Food Chem
Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice. [Abstract]2022 Feb 9;70(5):1536-1546. PMID: 35084179 -
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Eur J Pharmacol
Bruceine D inhibits CAF-promoted angiogenesis of breast cancer via suppressing IL-6-mediated activation of the STAT3/Notch1/VEGFR2 axis. [Abstract]2025 Sep 15:1003:177994. PMID: 40714073 -
Microb Pathog
Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice. [Abstract]2020 Jan:138:103826. PMID: 31676364 -
Am J Cancer Res
PRDM16 from hepatic stellate cells-derived extracellular vesicles promotes hepatocellular carcinoma progression. [Abstract]2023 Nov 15;13(11):5254-5270. PMID: 38058806 -
Biochem Biophys Res Commun
Tangeretin protects mice from diet-induced metabolic inflammation via activating adipose lactate accumulation and macrophage M2 polarization. [Abstract]2022 Nov 19:630:16-23. PMID: 36126465 -
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Biomed Pharmacother
Developing neobavaisoflavone nanoemulsion suppresses lung cancer progression by regulating tumor microenvironment. [Abstract]2020 Sep:129:110369. PMID: 32563983
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (67.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 1 mg/mL (2.69 mM); Suspended solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocolo
Cell Assay
The effect of tangeretin on RAW264.7 cells was determined using a MTT assay as previously reported.(13) Briefly, RAW264.7 cells (1 × 104 cells/well) were seeded in a 96-well plate for 24 h and treated with different concentrations of tangeretin (6.3–50.0 μM) and dimethyl sulfoxide (DMSO) (vehicle control, 0.01 and 0.1%) for 10 or 48 h. The absorbance was measured at 570 nm using an enzyme immunoassay (EIA) reader (Thermo Scientific, Waltham, MA), and cell viability (%) was calculated as follows: [(absorbance of the test group – absorbance of the blank control)/(absorbance of the control group – absorbance of the blank control)] × 100.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
Animal administration [2] The mice were maintained in an air-conditioned, pathogen-free room (temperature of 24 ± 2 °C, with a 12 h light/dark cycle from 6:00 am to 6:00 pm) with free access to food and water. Mice were randomly divided into five groups (n = 10) as follows: normal (control), RSV-challenged, and three treatment groups administered 25, 50, or 100 mg/kg/day tangeretin dissolved in saline. The control and RSV-challenged groups received equal volumes of saline. During the experiment, mice in the treatment groups were intragastrically administrated tangeretin for 3 days consecutively before RSV stimulation. Mice were lightly anesthetized with diethyl ether and intranasally challenged with RSV Long strain [6.7 × 106 plaque-forming units (PFU)] on day 4 after tangeretin treatment, while the control group was sham-infected with an equal volume of HEp-2 cell lysate, which was centrifuged under the same conditions as the viral suspensions. The mice were weighed during the experiment and sacrificed on day 5 post-infection after anesthetizing them with chloral hydrate (Figure 1B). The lung tissues were removed and weighed, and the lung index was calculated using the following formula: lung index = lung weight/body weight.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10. [Content Brief]
[2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7. [Content Brief]
[3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2017 Jun;56(4):1609-1620. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6855 mL | 13.4275 mL | 26.8550 mL | 67.1375 mL |
| 5 mM | 0.5371 mL | 2.6855 mL | 5.3710 mL | 13.4275 mL | |
| 10 mM | 0.2686 mL | 1.3428 mL | 2.6855 mL | 6.7138 mL | |
| 15 mM | 0.1790 mL | 0.8952 mL | 1.7903 mL | 4.4758 mL | |
| 20 mM | 0.1343 mL | 0.6714 mL | 1.3428 mL | 3.3569 mL | |
| 25 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6855 mL | |
| 30 mM | 0.0895 mL | 0.4476 mL | 0.8952 mL | 2.2379 mL | |
| 40 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6784 mL | |
| 50 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3428 mL | |
| 60 mM | 0.0448 mL | 0.2238 mL | 0.4476 mL | 1.1190 mL |
Tangeretin Related Classifications
HY-N0133 Related Classifications
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