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Referencia número: HY-144431

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Bcl-2/Mcl-1-IN-3

Name: Bcl-2/Mcl-1-IN-3
Brand: MedChemExpress
SKU: HY-144431
Availability: PreOrder

Bcl-2/Mcl-1-IN-3 (compound 1) is a Bcl-2/Mcl-1 inhibitor, with K_is of 0.14 μM and 0.23 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer.

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No. CAS: 2088981-53-5

Fòrmula: C₂₇H₂₆ClNO₄

Peso molecular:463.95

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Bcl-2/Mcl-1-IN-3 Chemical Structure

No. CAS: 2088981-53-5

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Data Download

Data Sheet (268 KB)

Instrucciones de manejo (2659 KB)

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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec

Actividad biológica

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Ver todos los productos específicos de isoformas Bcl-2 Family
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Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

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Bim

BNIP3

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Actividad biológica

Descripciòn

Bcl-2/Mcl-1-IN-3 (compound 1) is a Bcl-2/Mcl-1 inhibitor, with K_is of 0.14 μM and 0.23 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer^[1].

IC₅₀ & Target
^[1]

Mcl-1

0.14 μM (Ki)

Bcl-2

0.23 μM (Ki)

Bcl-xL

15 μM (Ki)

Ver todos los productos específicos de isoformas Bcl-2 Family :

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

BNIP3

Bad

Chemical Information

No. CAS 2088981-53-5

Peso molecular 463.95

Fòrmula C₂₇H₂₆ClNO₄

SMILES

O=C(O)C1=CC=CC=C1COC2=CC=CC3=C2C=CN3CCCOC4=CC(C)=C(Cl)C(C)=C4

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Concentration Concentration

×
Volume Volume

×
Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bcl-2/Mcl-1-IN-3 Related Classifications

HY-144431 Related Classifications

Apoptosis

Bcl-2 Family

Disease Areas

Cancer

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

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Keywords

Bcl-2/Mcl-1-IN-3
2088981-53-5
Bcl-2 Family
Inhibitor
inhibitor
inhibit

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Bcl-2/Mcl-1-IN-3

Ver todos los productos específicos de isoformas Bcl-2 Family

Actividad biológica

Descripciòn

IC50 & Target

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Bcl-2/Mcl-1-IN-3 Related Classifications

HY-144431 Related Classifications

Bioz

Keywords

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