BmP02
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells.
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- Fòrmula: C115H182N36O41S7
- Peso molecular:2949.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Kv1.3, Kv4.2[1]
Chemical Information
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Peso molecular 2949.35
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Fòrmula C115H182N36O41S7
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Sequence
Val-Gly-Cys-Glu-Glu-Cys-Pro-Met-His-Cys-Lys-Gly-Lys-Asn-Ala-Lys-Pro-Thr-Cys-Asp-Asp-Gly-Val-Cys-Asn-Cys-Asn-Val (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
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Sequence Shortening
VGCEECPMHCKGKNAKPTCDDGVCNCNV (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Wu B, et al. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431. [Content Brief]
[2]. Wu B, et al. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel). 2016 Sep 27;8(10):280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BmP02 Related Classifications
HY-P5157 Related Classifications
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