BP-1-108
BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1334492-85-1
- Fòrmula: C32H38N2O6S
- Peso molecular:578.72
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
STAT5 8.3 μM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
42 μM
Compound: BP-1-108
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Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
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[PMID: 22148584] |
| MV4-11 | IC50 |
17 μM
Compound: BP-1-108
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Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
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[PMID: 22148584] |
| NIH3T3 | IC50 |
100 μM
Compound: BP-1-108
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Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay
Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay
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[PMID: 22148584] |
Chemical Information
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No. CAS 1334492-85-1
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Peso molecular 578.72
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Fòrmula C32H38N2O6S
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SMILES
O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BP-1-108 Related Classifications
HY-125151 Related Classifications
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