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Referencia número: HY-168569

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DDD489

DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC₅₀ values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo.

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No. CAS: 3003871-42-6
Fòrmula: C₁₅H₁₆F₆N₄O
Peso molecular:382.30

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DDD489 Chemical Structure

No. CAS: 3003871-42-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC₅₀ values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo^[1].

Chemical Information

No. CAS 3003871-42-6
Peso molecular 382.30
Fòrmula C₁₅H₁₆F₆N₄O
SMILES

O=C1N(C[C@H]2C[C@@H](C(F)(F)F)CCC2)CC3=NC(N)=NC(C(F)(F)F)=C31
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Caldwell N, et al. Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy. Sci Transl Med. 2024;16(770):eadm8631. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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