DMPG
DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) is a phospholipid that can be used for preparing formulations such as liposomes or gels. DMPG can be used in the research of drug delivery.
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- No. CAS: 185463-22-3
- Fòrmula: C34H67O10P
- Peso molecular:666.86
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
DMPG has been shown
to present a large gel-fluid transition region, ranging from 18 to 35 ℃[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Parmacokinetics
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t | MRT0-t |
|---|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | i.p. | 1.87 ± 0.28 h | 0.73 ± 0.34 h | 261.9 ± 146.2 ng/mL | 188.5 ± 119.3 ng·h/mL | 1.65 ± 0.37 h |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crl:CD(SD) rats (225 ± 25 g, equal gender distribution, SPF grade)[1]
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Dosage:1.6 mg/kg, 3.2 mg/kg, 4.8 mg/kg
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Administration:i.v.; single dose
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Result:Exhibited elimination half-life values of 1.081 ± 0.277 h (1.6 mg/kg), 1.448 ± 0.287 h (3.2 mg/kg), 2.348 ± 0.325 h (4.8 mg/kg) when administered alone.
Showed maximum plasma concentration (Cmax) values of 10168.9 ± 2262.1 μg/L (1.6 mg/kg), 14904.4 ± 1706.4 μg/L (3.2 mg/kg), 78723.6 ± 56402.7 μg/L (4.8 mg/kg) when administered alone.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 3586.7 ± 721.7 μg/L·h (1.6 mg/kg), 4913.1 ± 632.8 μg/L·h (3.2 mg/kg), 23248.4 ± 15236.8 μg/L·h (4.8 mg/kg) when administered alone.
Exhibited elimination half-life values of 8.078 ± 6.523 h (1.6 mg/kg), 4.561 ± 3.542 h (3.2 mg/kg), 4.645 ± 3.531 h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Showed maximum plasma concentration (Cmax) values of 3922.9 ± 2039.2 μg/L (1.6 mg/kg), 8201.2 ± 2227.9 μg/L (3.2 mg/kg), 10523.3 ± 2049.1 μg/L (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 1568.3 ± 695.5 μg/L·h (1.6 mg/kg), 3198.9 ± 695.5 μg/L·h (3.2 mg/kg), 5096.1 ± 1166.1 μg/L·h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Rapidly distributed to most tissues, with highest concentrations in lungs, liver, spleen, and kidneys; minimal levels detected in brain, heart, small intestine, muscle, testes, ovaries, uterus, adipose tissue, and stomach.
Chemical Information
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No. CAS 185463-22-3
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Peso molecular 666.86
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Fòrmula C34H67O10P
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SMILES
OCC(O)COP(OC[C@@H](COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O)(O)=O
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Synonyms
L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Yu Z, et al. Development of a UHPLC-MS/MS method for the quantification of DMPC and DMPG in rats and its pharmacokinetic and tissue distribution application. J Pharm Biomed Anal. 2026;269:117266. [Content Brief]
[2]. Lamy-Freund MT, et al. The peculiar thermo-structural behavior of the anionic lipid DMPG. Chem Phys Lipids. 2003;122(1-2):19-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMPG Related Classifications
HY-177191 Related Classifications
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