FD2157
FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light.
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- No. CAS: 3046403-79-3
- Fòrmula: C27H21ClN6O8S
- Peso molecular:625.01
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
8.8 μM
Compound: FD2157
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Antiproliferative activity against mouse B16 cells assessed as reduction in cell viability incubated for 48 hrs irradiated with 365 nm uv light for 4 min by CCK-8 assay
Antiproliferative activity against mouse B16 cells assessed as reduction in cell viability incubated for 48 hrs irradiated with 365 nm uv light for 4 min by CCK-8 assay
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[PMID: 37634762] |
Chemical Information
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No. CAS 3046403-79-3
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Peso molecular 625.01
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Fòrmula C27H21ClN6O8S
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SMILES
O=C(OCC1=CC(OC)=C(OC)C=C1[N+]([O-])=O)N(N=C2)C(C2=C3)=NC=C3C4=CN=C(Cl)C(NS(=O)(C5=CC=CC=C5)=O)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FD2157 Related Classifications
HY-155996 Related Classifications
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