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Referencia número: HY-115873

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Folate-MS432

Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

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No. CAS: 2769735-56-8
Fòrmula: C₇₇H₉₄F₃IN₁₈O₁₂S
Peso molecular:1679.65

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Folate-MS432 Chemical Structure

No. CAS: 2769735-56-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

Ver todos los productos específicos de isoformas PROTACs :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	246 nM Compound: 36	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 35763424]
HT-29	IC₅₀	436 nM Compound: 10; FA-MS432	Anticancer activity against human HT-29 cells assessed as cell growth inhibition Anticancer activity against human HT-29 cells assessed as cell growth inhibition	[PMID: 37317568]
HT-29	IC₅₀	436 nM Compound: 62	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 34656901]
SK-MEL-28	IC₅₀	390 nM Compound: 62	Antiproliferative activity against human SK-MEL-28 cells Antiproliferative activity against human SK-MEL-28 cells	[PMID: 34656901]

Chemical Information

No. CAS 2769735-56-8
Peso molecular 1679.65
Fòrmula C₇₇H₉₄F₃IN₁₈O₁₂S
SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liu J, et al. Cancer Selective Target Degradation by Folate-Caged PROTACs. J Am Chem Soc. 2021 May 19;143(19):7380-7387. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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