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MYO1C - myosin IC Gene

Also Known as NMI; MMIb; myr2; MyoIC; MMI-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4641

About MYO1C

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,464,186-1,492,686 (from NCBI)

This gene has 20 transcripts (splice variants), 205 orthologues, 43 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues.

Summary

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene Myosin IE has been referred to as Myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

MYO1C Products (4)

mRNA	Protein	Name
NM_001080779.2	NP_001074248.1	unconventional myosin-Ic isoform a
NM_001080950.2	NP_001074419.1	unconventional myosin-Ic isoform b
NM_001363855.1	NP_001350784.1	unconventional myosin-Ic isoform d
NM_033375.5	NP_203693.3	unconventional myosin-Ic isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21402783	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21402783	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21402783	GOA
involved in positive regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	16603771	GOA
involved in protein targeting to membrane	IDA IDA: Inferred from direct assay	21402783	GOA
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	23262137	GOA
involved in regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	21402783	GOA
involved in vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	23262137	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
part of B-WICH complex	IDA IDA: Inferred from direct assay	16603771	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21402783	GOA
located in membrane	IDA IDA: Inferred from direct assay	21402783	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	23262137	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23262137	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO1C Protein Structure

Myosin_head

Myosin_TH1

0
200
400
600
800
1000
1063 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-Ic	myosin-I beta

Related Diseases

Diseases	Alias
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Deafness Type Dfna Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna Autosomal Dominant Isolated Sensorineural Deafness Type Dfna Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Granulomatous Amebic Encephalitis	Granulomatous Amoebic Encephalitis Acanthamoeba Encephalitis Acanthamoeba Granulomatous Encephalitis Granulomatous Amebic Encephalitis Due To Acanthamoeba
Chromosome 17p13.3, Centromeric, Duplication Syndrome	Chromosome 17p13.3 Duplication Syndrome 17p13.3 Duplication Syndrome 17p13.3 Microduplication Syndrome Trisomy 17p13.3 Chromosome 17p13.3 Centromeric Duplication Syndrome Dup(17)(P13.3)
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Miller-Dieker Lissencephaly Syndrome	Miller-Dieker Syndrome Mds MDLS Miller Dieker Syndrome Classical Lissencephaly Syndrome Lissencephaly Due To 17p13.3 Deletion Monosomy 17p13.3 Telomeric Deletion 17p Classical Lissencephaly
Amebiasis	Amoebiasis Entamoebiasis Chronic Intestinal Amebiasis Amoebiasis, Unspecified Amebic Colitis Amoebic Enteritis Infection Due To Entamoeba Histolytica Amoebic Infection Disease Due To Endamoebidae Amoebiasis Nos
Usher Syndrome, Type I	USH1 Usher Syndrome Type 1 Us1 Usher Syndrome, Type 1b Usher Syndrome Type 1e Retinitis Pigmentosa And Congenital Deafness Usher Syndrome, Type Ie USH1E Usher Syndrome, Type 1e Usher Syndrome, Type 1a Usher Syndrome, Type Ib Usher Syndrome Type 1b Usher Syndrome Type Ie Usher Syndrome Type I Usher 1 Usher Syndrome, Type 1 Ush1a Usher Syndrome, Type I, French Variety Usher Syndrome, Type Ia Usher Syndrome 1b USH1B Usher'S Syndrome Type 1b Usher Syndrome Type Ib Ushib
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08939	MYO1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08941	MYO1E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21659	Myo1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28177	Myo1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYO1C	VGNC	VGNC:68390
Macaca mulatta	MYO1C	VGNC	VGNC:75112
Bos taurus	MYO1C	VGNC	VGNC:31818
Mus musculus	MYO1C	MGD	MGI:106612
Rattus norvegicus	MYO1C	RGD	RGD:620443
Canis familiaris	MYO1C	VGNC	VGNC:43562
Others	MYO1C	NCBI