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Referencia número: HY-160528

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IBG3

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC₅₀ values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia.

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Pureza: 98.53%
Fòrmula: C₅₄H₅₇N₉O₅S₂
Peso molecular:976.22

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBG3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

BRD2

8.6 pM (DC₅₀)

BRD4

6.7 pM (DC₅₀)

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

In Vitro

IBG3 (6 h) potently degrades BRD4^Tandem in KBM7 cells, with a DC₅₀ value of 6.7 pM, which is more potent than IBG1 and dBET6^[1].
IBG3 (1 nM-10 μM; 30 min) promotes the formation of the BRD4-DCAF16 ternary complex in vitro, with an EC₅₀ of 32 nM, and exhibits stronger complex-stabilizing activity compared with IBG1^[1].
IBG3 (1 pM-100 μM; 5 h) potently degrades BRD2 (DC₅₀ = 8.6 pM) and BRD4 in HEK293 HiBiT knock-in cells, but shows no effect on BRD3, with higher efficiency than IBG1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Peso molecular 976.22
Fòrmula C₅₄H₅₇N₉O₅S₂
Color Off-white to light yellow
SMILES

O=C(NCC1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1)C5=CC=C(C6=CC=C(C7=N[C@@H](CC(OC(C)(C)C)=O)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C=C5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Structure

CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1. [Abstract]

2026 Mar 20:S0969-2126(26)00056-0. PMID: 41864201

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (102.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0244 mL

5.1218 mL

10.2436 mL

5 mM

0.2049 mL

1.0244 mL

2.0487 mL

10 mM

0.1024 mL

0.5122 mL

1.0244 mL

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hsia O, et al. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024;627(8002):204-211. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0244 mL	5.1218 mL	10.2436 mL	25.6090 mL
	5 mM	0.2049 mL	1.0244 mL	2.0487 mL	5.1218 mL
	10 mM	0.1024 mL	0.5122 mL	1.0244 mL	2.5609 mL
	15 mM	0.0683 mL	0.3415 mL	0.6829 mL	1.7073 mL
	20 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2804 mL
	25 mM	0.0410 mL	0.2049 mL	0.4097 mL	1.0244 mL
	30 mM	0.0341 mL	0.1707 mL	0.3415 mL	0.8536 mL
	40 mM	0.0256 mL	0.1280 mL	0.2561 mL	0.6402 mL
	50 mM	0.0205 mL	0.1024 mL	0.2049 mL	0.5122 mL
	60 mM	0.0171 mL	0.0854 mL	0.1707 mL	0.4268 mL
	80 mM	0.0128 mL	0.0640 mL	0.1280 mL	0.3201 mL
	100 mM	0.0102 mL	0.0512 mL	0.1024 mL	0.2561 mL

Keywords

IBG3

1 Cited Publications

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias

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IBG3

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Molecular Glue Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IBG3

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

IBG3

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Molecular Glue Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IBG3

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

IBG3 Related Classifications

HY-160528 Related Classifications