L-869298
L-869298 is a potent and selective PDE4 inhibitor with an IC50 of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 362718-73-8
- Fòrmula: C23H18F8N2O4S
- Peso molecular:570.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PDE4A 0.5 nM (IC50) |
Chemical Information
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No. CAS 362718-73-8
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Peso molecular 570.45
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Fòrmula C23H18F8N2O4S
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SMILES
OC(C(F)(F)F)(C1=NC=C(S1)[C@@H](CC2=C[N+]([O-])=CC=C2)C3=CC=C(C(OC4CC4)=C3)OC(F)F)C(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Richard W Friesen, et al. Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. J Med Chem. 2003 Jun 5;46(12):2413-26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-869298 Related Classifications
HY-122167 Related Classifications
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