OPC 33540
OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies.
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- No. CAS: 189362-27-4
- Fòrmula: C27H39N3O4
- Peso molecular:469.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PDE3A 0.32 nM (IC50) |
PDE3B 1.5 nM (IC50) |
PDEI 42.9 μM (IC50) |
PDE2 52.3 μM (IC50) |
PDE4 100.8 μM (IC50) |
PDE7 51.3 μM (IC50) |
PDE5 2.5 μM (IC50) |
In Vitro
Chemical Information
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No. CAS 189362-27-4
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Peso molecular 469.62
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Fòrmula C27H39N3O4
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SMILES
O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CCCCCCC3)[C@H]4[C@H](O)CCCC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OPC 33540 Related Classifications
HY-112631 Related Classifications
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