OPC 33540
OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies.
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- No. CAS: 189362-27-4
- Fòrmula: C27H39N3O4
- Peso molecular:469.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PDE3A 0.32 nM (IC50) |
PDE3B 1.5 nM (IC50) |
PDEI 42.9 μM (IC50) |
PDE2 52.3 μM (IC50) |
PDE4 100.8 μM (IC50) |
PDE7 51.3 μM (IC50) |
PDE5 2.5 μM (IC50) |
In Vitro
OPC-33540 (0.1-100 nM) exhibits concentration-dependent increase in platelet cAMP levels and strongly inhibits platelet aggregation induced by thrombin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 189362-27-4
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Peso molecular 469.62
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Fòrmula C27H39N3O4
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SMILES
O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CCCCCCC3)[C@H]4[C@H](O)CCCC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OPC 33540 Related Classifications
HY-112631 Related Classifications
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