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Referencia número: HY-12476

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SAR156497

SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC₅₀ value of 4 μM. SAR156497 can be used in anticancer research.

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No. CAS: 1256137-14-0
Fòrmula: C₂₇H₂₄N₄O₄
Peso molecular:468.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SAR156497 Chemical Structure

No. CAS: 1256137-14-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target

PDE3

4 μM (IC₅₀)

Aurora A

0.6 nM (IC₅₀)

Aurora B

1 nM (IC₅₀)

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

Ver todos los productos específicos de isoformas Aurora Kinase :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	3.714 μM Compound: SAR156497	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HEK293	IC₅₀	5.864 μM Compound: SAR156497	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	0.00611 μM Compound: SAR156497	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	67 nM Compound: 47	Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis	[PMID: 25369539]
PBMC	IC₅₀	>10 μM Compound: 47	Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay	[PMID: 25369539]
PC-3	IC₅₀	12.58 μM Compound: SAR156497	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]

Chemical Information

No. CAS 1256137-14-0
Peso molecular 468.50
Fòrmula C₂₇H₂₄N₄O₄
SMILES

O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Carry JC, et al. SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem. 2015 Jan 8;58(1):362-75. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SAR156497

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)

Ver todos los productos específicos de isoformas Aurora Kinase

Actividad biológica

Descripciòn

IC50 & Target

Cellular Effect

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SAR156497 Related Classifications

HY-12476 Related Classifications

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