Se-DMC
Based on 1 Customer Validation
Se-DMC attenuates complete Freund’s adjuvant (CFA)-induced inflammatory response, nociception, and neurobehavioral deficits in mice.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.88%
- No. CAS: 2098850-81-6
- Fòrmula: C13H15ClO3Se
- Peso molecular:333.67
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2098850-81-6
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Appearance Solid
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Peso molecular 333.67
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Fòrmula C13H15ClO3Se
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(C=C1)Cl)[Se]CC2OC(C)(C)OC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (149.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9970 mL | 14.9849 mL | 29.9697 mL | 74.9243 mL |
| 5 mM | 0.5994 mL | 2.9970 mL | 5.9939 mL | 14.9849 mL | |
| 10 mM | 0.2997 mL | 1.4985 mL | 2.9970 mL | 7.4924 mL | |
| 15 mM | 0.1998 mL | 0.9990 mL | 1.9980 mL | 4.9950 mL | |
| 20 mM | 0.1498 mL | 0.7492 mL | 1.4985 mL | 3.7462 mL | |
| 25 mM | 0.1199 mL | 0.5994 mL | 1.1988 mL | 2.9970 mL | |
| 30 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4975 mL | |
| 40 mM | 0.0749 mL | 0.3746 mL | 0.7492 mL | 1.8731 mL | |
| 50 mM | 0.0599 mL | 0.2997 mL | 0.5994 mL | 1.4985 mL | |
| 60 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2487 mL | |
| 80 mM | 0.0375 mL | 0.1873 mL | 0.3746 mL | 0.9366 mL | |
| 100 mM | 0.0300 mL | 0.1498 mL | 0.2997 mL | 0.7492 mL |
Se-DMC Related Classifications
HY-139703 Related Classifications
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