Isg15 - ISG15 ubiquitin-like modifier Gene

Also Known as G1p2; IP17; Irfp; UCRP; IGI15

Species: Mus musculus

Gene Type: protein coding

Gene ID: 100038882

Summary

Enables protein tag. Involved in several processes, including ISG15-protein conjugation; defense response to Other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]

Isg15 Products (1)

mRNA	Protein	Name
NM_015783.3	NP_056598.2	ubiquitin-like protein ISG15

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15485925	MGI
enables protein tag activity	IDA IDA: Inferred from direct assay	16139798	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ISG15-protein conjugation	IDA IDA: Inferred from direct assay	16139798	MGI
involved in ISG15-protein conjugation	IDA IDA: Inferred from direct assay	22022510	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	22859821	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	17227866	MGI
acts upstream of or within modification-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15485925	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21402791	MGI
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22022510	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ubiquitin-like protein ISG15	interferon, alpha-inducible protein interferon-induced 15 kDa protein interferon-induced 15-KDa protein interferon-induced 17 kDa protein interferon-stimulated protein (15 kDa) interferon-stimulated protein 15 ubiquitin cross-reactive protein

Isg15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Isg15	Q64339	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Cleavage	32726803
Cross	Isg15	Q64339	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Probe Interaction	32726803
Cross	Isg15	Q64339	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Cleavage	32726803
Cross	Isg15	Q64339	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	X-Ray Diffraction	32726803
Cross	Isg15	Q64339	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Protease Assay	32428392
Cross	Isg15	Q64339	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Protease Assay	32428392
Cross	Isg15	Q64339	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Probe Interaction	32726803
Intra	Isg15	Q64339	Usp18	Mus musculus	Q9WTV6	Enzymatic Study	24533902
Intra	Isg15	Q64339	Usp18	Mus musculus	Q9WTV6	MST	24533902
Intra	Isg15	Q64339	Usp18	Mus musculus	Q9WTV6	Probe Interaction	32726803
Intra	Isg15	Q64339	Usp18	Mus musculus	Q9WTV6	Cleavage	32726803

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-172969	ZHAWOC8655	Inhibitor	98.63%	Unkown
HY-152956	STING agonist-23	Agonist	99.33%	Unkown
HY-173425	STING-IN-15	Inhibitor	99.04%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-RS06929	ISG15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17041	Isg15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-168554	STING Degrader-3		/	Unkown
HY-172193	UBD1031	Antagonist	/	Unkown
HY-187197	GL-637	Inhibitor	/	Unkown
HY-174663	Human IFNE mRNA		/	Unkown
HY-RS23485	Isg15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Isg15	NCBI	NCBI:9636