ARL4C - ADP ribosylation factor like GTPase 4C Gene

Also Known as LAK; ARL7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10123

About ARL4C

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:234,493,041-234,497,081 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 30 paralogues. Broad expression in lymph node (RPKM 30.2), spleen (RPKM 30.0) and 20 other tissues.

Summary

ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in Cholesterol transport. [provided by RefSeq, Jul 2008]

ARL4C Products (2)

mRNA Protein Name
NM_001282431.2 NP_001269360.1 ADP-ribosylation factor-like protein 4C isoform 1
NM_005737.3 NP_005728.2 ADP-ribosylation factor-like protein 4C isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
19409876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17398095 GOA
Biological Process GO Annotation Evidence References Source
involved in endocytic recycling IDA
IDA: Inferred from direct assay
19409876 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19409876 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17398095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL4C Protein Structure

Arf

Arf: ADP-ribosylation factor family (8 - 179)

  • 0
  • 100
  • 192 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 4C

  • ADP ribosylation factor-like protein 7

Related Diseases

Diseases Alias
Vulvar Leiomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00989 ARL4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22395 Arl4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28919 Arl4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARL4C VGNC VGNC:38113
Felis catus ARL4C VGNC VGNC:80138
Rattus norvegicus ARL4C RGD RGD:1589685
Macaca mulatta ARL4C VGNC VGNC:70018
Bos taurus ARL4C VGNC VGNC:26145
Mus musculus ARL4C MGD MGI:2445172
Others ARL4C NCBI