Mapkapk3 - mitogen-activated protein kinase-activated protein kinase 3 Gene

Also Known as 3PK; MK3; MK-3; MAPKAP3; MAPKAP-K3; MapkKapk3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 102626

Summary

Predicted to enable Calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Involved in macropinocytosis; response to lipopolysaccharide; and Toll-like Receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; naris; skin; urinary system; and ventral grey horn. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk3 Products (2)

mRNA Protein Name
NM_001316691.1 NP_001303620.1 MAP kinase-activated protein kinase 3 isoform 2
NM_178907.3 NP_849238.1 MAP kinase-activated protein kinase 3 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in macropinocytosis IMP
IMP: Inferred from mutant phenotype
17906627 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17906627 MGI
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17906627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 3

  • MAPK-activated protein kinase 3

  • MAPKAP kinase 3

  • MAPKAPK-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-P10367 Ziptide / Unkown
HY-RS08134 MAPKAPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18320 Mapkapk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24798 Mapkapk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapkapk3 NCBI NCBI:7867