MAPKAPK3 - MAPK activated protein kinase 3 Gene

Also Known as 3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7867

About MAPKAPK3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:50,611,520-50,649,291 (from NCBI)

This gene has 8 transcripts (splice variants), 253 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in heart (RPKM 55.1), bone marrow (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

MAPKAPK3 Products (3)

mRNA	Protein	Name
NM_001243925.2	NP_001230854.1	MAP kinase-activated protein kinase 3
NM_001243926.2	NP_001230855.1	MAP kinase-activated protein kinase 3
NM_004635.5	NP_004626.1	MAP kinase-activated protein kinase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8774846	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	7799959	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8774846	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	8774846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAPK3 Protein Structure

Pkinase

0
100
200
300
382 a.a.

Protein Preferred Names	Protein Names
MAP kinase-activated protein kinase 3	MAPKAP kinase 3

MAPKAPK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPKAPK3	Q16644	MAPK11	Homo sapiens	Q15759	Anti Tag CoIP	33961781
Intra	MAPKAPK3	Q16644	MAPK11	Homo sapiens	Q15759	Anti Tag CoIP	28514442
Intra	MAPKAPK3	Q16644	MAPK11	Homo sapiens	Q15759	Anti Tag CoIP	35271311
Intra	MAPKAPK3	Q16644	MAPK11	Homo sapiens	Q15759	Pull Down	32707033
Intra	MAPKAPK3	Q16644	HSPB1	Homo sapiens	P04792	Protein Kinase Assay	21575178
Intra	MAPKAPK3	Q16644	HSPB1	Homo sapiens	P04792	PLA	25241761
Intra	MAPKAPK3	Q16644	MAPK14	Homo sapiens	Q16539	Pull Down	32707033
Intra	MAPKAPK3	Q16644	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	35271311
Cross	MAPKAPK3	Q16644	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Pull Down	23487458
Cross	MAPKAPK3	Q16644	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Anti Bait CoIP	23487458

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPKAPK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74763	MAPKAPK3 Protein, Human (sf9, GST)	Q16644 (M1-Q382)	≥ 90%, as determined by reducing SDS-PAGE.

MAPKAPK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83325	MAPKAP Kinase 3 Antibody (YA3070)	WB, IP	Human
HY-P83325A	MAPKAP Kinase 3 Antibody (YA3070)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Macular Dystrophy, Patterned, 3	Martinique Crinkled Retinal Pigment Epitheliopathy Patterned Macular Dystrophy 3 MDPT3 Mcrpe
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Patterned Macular Dystrophy	Patterned Dystrophy Of Retinal Pigment Epithelium
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-P10367	Ziptide		/	Unkown
HY-RS08134	MAPKAPK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18320	Mapkapk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24798	Mapkapk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAPKAPK3	RGD	RGD:1304980
Macaca mulatta	MAPKAPK3	VGNC	VGNC:74654
Mus musculus	MAPKAPK3	MGD	MGI:2143163
Bos taurus	MAPKAPK3	VGNC	VGNC:31229
Canis familiaris	MAPKAPK3	VGNC	VGNC:43007
Felis catus	MAPKAPK3	VGNC	VGNC:68176
Others	MAPKAPK3	NCBI