country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

LANCL1 - LanC like glutathione S-transferase 1 Gene

Also Known as p40; GPR69A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10314

About LANCL1

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,431,251-210,477,584 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues.

Summary

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of Bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

LANCL1 Products (3)

mRNA	Protein	Name
NM_001136574.2	NP_001130046.1	glutathione S-transferase LANCL1
NM_001136575.2	NP_001130047.1	glutathione S-transferase LANCL1
NM_006055.3	NP_006046.1	glutathione S-transferase LANCL1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19528316	GOA
enables glutathione binding	IDA IDA: Inferred from direct assay	19528316	GOA
enables low-density lipoprotein particle receptor binding	IDA IDA: Inferred from direct assay	15082773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19528316	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10944443	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	10944443	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LANCL1 Protein Structure

LANC_like

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
glutathione S-transferase LANCL1	40 kDa erythrocyte membrane protein

LANCL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LANCL1	O43813	BAIAP2L1	Homo sapiens	Q9UHR4	Validated Y2H	32296183
Intra	LANCL1	O43813	BAIAP2L1	Homo sapiens	Q9UHR4	Y2H Array	32296183
Intra	LANCL1	O43813	BAIAP2L1	Homo sapiens	Q9UHR4	Y2H Prey Pooling	32296183
Cross	LANCL1	O43813	Eps8	Mus musculus	Q08509	SPR	19528316
Intra	LANCL1	O43813	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	LANCL1	O43813	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	LANCL1	O43813	HTT	Homo sapiens	P42858	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Overhydrated Hereditary Stomatocytosis	Ohs Potassium Sodium Disorder Of Erythrocyte OHST Stomatocytosis I Potassium-Sodium Disorder Of Erythrocyte Stomatocytosisiohst Hereditary, Overhydrated, Cation-Leak Stomatocytosis Overhydrated Cation Leak Stomatocytosis Stomatocytosis, Overhydrated Hereditary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07518	LANCL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LANCL1	MGD	MGI:1336997
Bos taurus	LANCL1	VGNC	VGNC:30783
Felis catus	LANCL1	VGNC	VGNC:68016
Macaca mulatta	LANCL1	VGNC	VGNC:104541
Canis familiaris	LANCL1	VGNC	VGNC:42580
Rattus norvegicus	LANCL1	RGD	RGD:69416
Others	LANCL1	NCBI