Slc6a5 - solute carrier family 6 (neurotransmitter transporter, glycine), member 5 Gene

Also Known as Glyt2; prestin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104245

About Slc6a5

Chromosome 7: 49,559,894-49,613,604 forward strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 210 orthologues, 20 paralogues and is associated with 34 phenotypes. Biased expression in cerebellum adult (RPKM 13.1), CNS E14 (RPKM 1.8) and 2 other tissues.

Summary

Predicted to enable glycine:sodium symporter activity. Involved in neurotransmitter reuptake. Is active in glycinergic synapse. Is expressed in several structures, including adrenal gland; central nervous system; esophagus; lens; and male reproductive gland or organ. Used to study hyperekplexia 3. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a5 Products (2)

mRNA Protein Name
NM_001146013.1 NP_001139485.1 sodium- and chloride-dependent glycine transporter 2 isoform a
NM_148931.3 NP_683733.2 sodium- and chloride-dependent glycine transporter 2 isoform b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in neurotransmitter reuptake EXP
EXP: Inferred from Experiment
23486948 MGI
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
23486948 MGI
involved in neurotransmitter uptake IDA
IDA: Inferred from direct assay
14622583 MGI
involved in neurotransmitter uptake IMP
IMP: Inferred from mutant phenotype
14622583 MGI
Cellular Component GO Annotation Evidence References Source
is active in glycinergic synapse EXP
EXP: Inferred from Experiment
23486948 MGI
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
14622583 MGI
is active in glycinergic synapse IMP
IMP: Inferred from mutant phenotype
14622583 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a5 Protein Structure

SLC6sbd_GlyT2

SLC6sbd_GlyT2: cd11499 (192 - 788)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
Protein Preferred Names Protein Names

sodium- and chloride-dependent glycine transporter 2

  • glyT-2

  • glycine transporter 2

  • solute carrier family 6 member 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13306 SLC6A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13314 SLC6A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13315 Slc6a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13316 Slc6a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20194 Slc6a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a5 NCBI NCBI:9152