Card11 - caspase recruitment domain family, member 11 Gene

Also Known as BIMP3; CARMA1; 0610008L17Rik; 2410011D02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108723

Summary

Predicted to enable CARD domain binding activity and protein self-association. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (Caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Apr 2022]

Card11 Products (1)

mRNA Protein Name
NM_175362.2 NP_780571.2 caspase recruitment domain-containing protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12356734 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within B cell proliferation IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of T cell activation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within interleukin-2 production IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of or within lymphocyte activation IMP
IMP: Inferred from mutant phenotype
12818158 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12154356 MGI
acts upstream of or within positive regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
involved in positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12154356 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12154356 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
12867038 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12356734 MGI
acts upstream of or within thymic T cell selection IMP
IMP: Inferred from mutant phenotype
12867038 MGI
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
23793062 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12867038 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caspase recruitment domain-containing protein 11

  • CARD-containing MAGUK protein 1

  • carma 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142648 MLT-985 Inhibitor 99.49% Unkown
HY-174371 INNO-220 98.60% Unkown
HY-142648A (R)-MLT-985 Inhibitor / Unkown
HY-182706 NSC 373981 Inhibitor / Unkown
HY-RS01916 CARD11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17847 Card11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24315 Card11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Card11 NCBI NCBI:84433