Gusb - glucuronidase, beta Gene

Also Known as g; Gur; Gus; Gut; asd; Gus-r; Gus-s; Gus-t; Gus-u

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110006

Summary

Enables beta-glucuronidase activity. Acts upstream of or within glucuronoside catabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and viscerocranium. Used to study Sly syndrome. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Apr 2022]

Gusb Products (4)

mRNA Protein Name
NM_001357025.1 NP_001343954.1 beta-glucuronidase isoform 2
NM_001357026.1 NP_001343955.1 beta-glucuronidase isoform 3 precursor
NM_001357027.1 NP_001343956.1 beta-glucuronidase isoform 4 precursor
NM_010368.2 NP_034498.1 beta-glucuronidase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-glucuronidase activity IDA
IDA: Inferred from direct assay
1914521 MGI
enables beta-glucuronidase activity IMP
IMP: Inferred from mutant phenotype
9774663 MGI
enables hydrolase activity IDA
IDA: Inferred from direct assay
19710420 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within carbohydrate metabolic process IDA
IDA: Inferred from direct assay
4841576 MGI
involved in chondroitin sulfate catabolic process IMP
IMP: Inferred from mutant phenotype
23897660 MGI
involved in heparan sulfate proteoglycan catabolic process IMP
IMP: Inferred from mutant phenotype
11273777 MGI
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
20385825 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19710420 MGI
is active in lysosomal lumen IDA
IDA: Inferred from direct assay
8200966 MGI
is active in lysosomal lumen IMP
IMP: Inferred from mutant phenotype
23897660 MGI
is active in lysosome IDA
IDA: Inferred from direct assay
4841576 MGI
located in lysosome IDA
IDA: Inferred from direct assay
4841576 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-glucuronidase

  • adipose storage deficiency

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05927 GUSB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20750 Gusb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27262 Gusb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gusb NCBI NCBI:2990