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RAB35 - RAB35, member RAS oncogene family Gene

Also Known as RAY; H-ray; RAB1C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11021

About RAB35

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,095,099-120,116,753 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 68 paralogues. Ubiquitous expression in spleen (RPKM 16.4), appendix (RPKM 14.7) and 25 other tissues.

Summary

Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]

RAB35 Products (2)

mRNA	Protein	Name
NM_001167606.2	NP_001161078.1	ras-related protein Rab-35 isoform 2
NM_006861.7	NP_006852.1	ras-related protein Rab-35 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	16950109	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17562788	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	16950109	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	21951725	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell projection membrane	IDA IDA: Inferred from direct assay	16950109	GOA
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	16950109	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	16950109	GOA
located in intercellular bridge	IDA IDA: Inferred from direct assay	16950109	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16950109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB35 Protein Structure

Ras

0
100
201 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-35	GTP-binding protein RAY

RAB35 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RAB35	Q15286	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RAB35	Q15286	MICALL1	Homo sapiens	Q8N3F8	Y2H	21951725
Intra	RAB35	Q15286	MICALL1	Homo sapiens	Q8N3F8	Anti Tag CoIP	21951725
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	RAB35	Q15286	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB35 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810972	RAB35 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Familial Renal Oncocytoma
Lowe Oculocerebrorenal Syndrome	Lowe Syndrome Oculocerebrorenal Syndrome OCRL Oculocerebrorenal Syndrome Of Lowe Ocrl1 Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency Lowe Disease Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency Cerebrooculorenal Syndrome Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency Lowe Oculo-Cerebro-Renal Dystrophy Lowe Oculo-Cerebro-Renal Syndrome Lowe Oculocerebrorenal Dystrophy Low Chromosome 11p Deletion Syndrome Oculocerebrorenal Dystrophy Cerebro-Oculorenal Dystrophy Ocrl1 - [Oculocerebrorenal Syndrome] Lowe-Terrey-Maclachlan Syndrome Renal-Oculocerebrodystrophy
Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome	Door Syndrome Doors Syndrome Digitorenocerebral Syndrome Autosomal Recessive Deafness-Onychodystrophy Syndrome Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome DOORS Drc Syndrome Eronen Syndrome Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Brachydactyly Due To Absence Of Distal Phalanges Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome Deafness, Congenital Onychodystrophy, Recessive Form Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11549	RAB35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22762	Rab35 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29276	Rab35 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB35	RGD	RGD:1306362
Felis catus	RAB35	VGNC	VGNC:107720
Canis familiaris	RAB35	VGNC	VGNC:45278
Bos taurus	RAB35	VGNC	VGNC:33644
Mus musculus	RAB35	MGD	MGI:1924657
Others	RAB35	NCBI