LILRB3 - leukocyte immunoglobulin like receptor B3 Gene

Also Known as HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11025

About LILRB3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,216,278-54,223,007 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 317 orthologues and 25 paralogues. Biased expression in appendix (RPKM 14.3), bone marrow (RPKM 8.1) and 7 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB3 Products (3)

mRNA Protein Name
NM_001081450.3 NP_001074919.2 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor
NM_001320960.2 NP_001307889.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 3 precursor
NM_006864.4 NP_006855.3 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables amyloid-beta binding IDA
IDA: Inferred from direct assay
24052308 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18802077 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
18802077 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB3 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 115)

Ig_2

Ig_2: Immunoglobulin domain (123 - 216)

Ig_2

Ig_2: Immunoglobulin domain (228 - 315)

Ig_3

Ig_3: Immunoglobulin domain (326 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 648 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 3

  • CD85 antigen-like family member A

Recombinant LILRB3 Proteins

Cat. No. Product Name Accession Purity
HY-P75912 LILRB3/CD85a Protein, Human (HEK293, Fc) AAI04994.1 (G24-E443) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75913 LILRB3/CD85a Protein, Human (Biotinylated, HEK293, His) O75022 (G24-E443) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75914 LILRB3/CD85a Protein, Human (HEK293, His) O75022 (G24-E443) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78171 LILRB3/CD85a Protein, Human (Biotinylated, HEK293, His-Avi) O75022 (G24-E443) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78484 LILRB3/CD85a Protein, Human (HEK293, His-Avi) O75022 (G24-E443) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78665 LILRB3/CD85a Protein, Human (P288R, HEK293, His) O75022 (G24-E443, P288R) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78666 LILRB3/CD85a Protein, Human (P288R, HEK293, Fc) O75022 (G24-E443, P288R) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78840 LILRB3/CD85a Protein, Human (Biotinylated, HEK293, Fc-Avi) AAI12199 (G24-E443) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Takayasu Arteritis

  • Aortic Arch Syndrome

  • Pulseless Disease

  • Takayasu'S Arteritis

  • Idiopathic Aortitis

  • Young Female Arteritis

  • Aortic Arch Arteritis

  • Aortic Arches Defect

  • Aortic Arch Defects

  • Takayasu Disease

  • Aortic Arch Syndromes

  • Takayasu'S Disease

  • Ta

  • Obliterative Aortitis

  • Aortic Arch Giant-Cell Arteritis

  • Subclavian-Carotid Obstruction Syndrome

  • Idiopathic Medial Aortopathy And Arteriopathy

  • Takayasu Syndrome

  • Obliterative Brachiocephalic Arteritis Syndrome

  • Raeder-Harbitz Syndrome

  • Chronic Subclavian-Carotid Obstruction Syndrome

  • Giant-Cell Aortitis

  • Takayasu Aortitis

  • Nonspecific Aortoarteritis

  • Sclerosing Aortitis And Arteritis

  • Martorell 2 Syndrome

  • Young Female Aortic Arch Arteritis Syndrome
Anencephaly

  • Aprosencephaly

  • Anencephalus

  • Congenital Absence Of Brain

  • Absence Of A Large Part Of The Brain And The Skull

  • Anencephalia

  • Anencephalic Monster

  • Brain Absence

  • Brain Agenesis

  • Brain Aplasia

  • Absent Brain

  • Anencephalic

  • Congenital Absence Of Cerebrum

  • Congenital Hemicrania

  • Incomplete Anencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992215 Anti-CD85a/LILRB3 Antibody (7C5) / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LILRB3 RGD RGD:1589827