LILRA2 - leukocyte immunoglobulin like receptor A2 Gene

Also Known as ILT1; LIR7; CD85H; LIR-7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11027

About LILRA2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,572,988-54,590,287 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 335 orthologues and 25 paralogues. Biased expression in bone marrow (RPKM 15.6), spleen (RPKM 8.6) and 5 other tissues.

Summary

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

LILRA2 Products (4)

mRNA	Protein	Name
NM_001130917.3	NP_001124389.2	leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a precursor
NM_001290270.1	NP_001277199.1	leukocyte immunoglobulin-like receptor subfamily A member 2 isoform c precursor
NM_001290271.2	NP_001277200.1	leukocyte immunoglobulin-like receptor subfamily A member 2 isoform d precursor
NM_006866.4	NP_006857.2	leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables IgM binding	IDA IDA: Inferred from direct assay	27572839	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response activating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	27572839	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in neutrophil activation involved in immune response	IDA IDA: Inferred from direct assay	27572839	GOA
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	12393390	GOA
involved in positive regulation of cell activation	IDA IDA: Inferred from direct assay	12393390	GOA
involved in positive regulation of granulocyte colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	12393390	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12393390	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22479404	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12393390	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22479404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRA2 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
100
200
300
400
483 a.a.

Protein Preferred Names	Protein Names
leukocyte immunoglobulin-like receptor subfamily A member 2	CD85 antigen-like family member H

Recombinant LILRA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70875	LILRA2/CD85h/ILT1 Protein, Human (HEK293, His)	AAH17412.1 (G24-S420)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77983	LILRA2/CD85h/ILT1 Protein, Human (HEK293, His-Avi)	Q8N149-1 (G24-N449)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78850	LILRA2/CD85h/ILT1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8N149-1 (G24-N449)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07646	LILRA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown