Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Also Known as MR; Mlr

Species: Mus musculus

Gene Type: protein coding

Gene ID: 110784

About Nr3c2

Chromosome 8: 77,626,070-77,971,641 forward strand.GRCm39:CM001001.3

This gene has 8 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 23 phenotypes. Broad expression in colon adult (RPKM 12.), frontal lobe adult (RPKM 3.4) and 2 other tissues.

Summary

Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 Products (1)

mRNA	Protein	Name
NM_001083906.2	NP_001077375.1	mineralocorticoid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11809749	MGI
enables steroid binding	IDA IDA: Inferred from direct assay	11809749	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	24206662	MGI
acts upstream of or within intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	9689096	MGI
involved in potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	24206662	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	18547242	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	18547242	MGI
involved in regulation of blood volume by renal aldosterone	IMP IMP: Inferred from mutant phenotype	24206662	MGI
involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	18547242	MGI
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	18547242	MGI
involved in regulation of potassium:proton exchanging ATPase activity	IDA IDA: Inferred from direct assay	24206662	MGI
acts upstream of or within renal sodium excretion	IMP IMP: Inferred from mutant phenotype	9689096	MGI
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	24206662	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	18547242	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	18547242	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	18547242	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18547242	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c2 Protein Structure

Herpes_BLLF1

NR_DBD_GR_PR

NR_LBD_MR

0
200
400
600
800
980 a.a.

Protein Preferred Names	Protein Names
mineralocorticoid receptor	aldosterone receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09547	NR3C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09548	Nr3c2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09549	Nr3c2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr3c2	NCBI	NCBI:4306