BTN3A2 - butyrophilin subfamily 3 member A2 Gene

Also Known as BTF4; BT3.2; CD277; BTN3.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11118

About BTN3A2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,365,169-26,378,320 (from NCBI)

This gene has 19 transcripts (splice variants), 33 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 42.7), appendix (RPKM 22.0) and 24 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the Other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

BTN3A2 Products (5)

mRNA Protein Name
NM_001197246.2 NP_001184175.1 butyrophilin subfamily 3 member A2 isoform a precursor
NM_001197247.3 NP_001184176.1 butyrophilin subfamily 3 member A2 isoform a precursor
NM_001197248.3 NP_001184177.1 butyrophilin subfamily 3 member A2 isoform b
NM_001197249.3 NP_001184178.1 butyrophilin subfamily 3 member A2 isoform c
NM_007047.5 NP_008978.2 butyrophilin subfamily 3 member A2 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29339503 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
22767497 GOA
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
21918970 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22767497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN3A2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (31 - 134)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 3 member A2

  • butyrophilin protein

BTN3A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTN3A2 P78410 BTN3A1 Homo sapiens O00481
Anti Tag CoIP
33961781
Intra
BTN3A2 P78410 BTN3A1 Homo sapiens O00481
Confocal
29339503
Intra
BTN3A2 P78410 BTN3A1 Homo sapiens O00481
Anti Tag CoIP
29339503
Intra
BTN3A2 P78410 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
BTN3A2 P78410 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
BTN3A2 P78410 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN3A2 Proteins

Cat. No. Product Name Accession Purity
HY-P7684 BTN3A2 Protein, Human (HEK293, His) P78410-1 (Q30-W248) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72346 BTN3A2 Protein, Human (Biotinylated, HEK293, His-Avi) P78410-1 (Q30-W248) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78367 BTN3A2 Protein, Human (HEK293, His-Avi) P78410-1 (Q30-W248) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01674 BTN3A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26643 Btn3a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown