NUDT3 - nudix hydrolase 3 Gene

Also Known as DIPP; DIPP1; DIPP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11165

About NUDT3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,279,679-34,392,669 (from NCBI)

This gene has 1 transcript (splice variant), 227 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 33.6), thyroid (RPKM 19.6) and 25 other tissues.

Summary

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

NUDT3 Products (1)

mRNA Protein Name
NM_006703.4 NP_006694.1 diphosphoinositol polyphosphate phosphohydrolase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
IDA: Inferred from direct assay
32727897 GOA
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
IDA: Inferred from direct assay
32727897 GOA
enables diphosphoinositol-polyphosphate diphosphatase activity IDA
IDA: Inferred from direct assay
9822604 GOA
enables endopolyphosphatase activity IDA
IDA: Inferred from direct assay
34788624 GOA
enables inositol diphosphate pentakisphosphate diphosphatase activity IDA
IDA: Inferred from direct assay
9822604 GOA
enables inositol diphosphate pentakisphosphate diphosphatase activity IMP
IMP: Inferred from mutant phenotype
10585413 GOA
enables inositol diphosphate tetrakisphosphate diphosphatase activity IDA
IDA: Inferred from direct assay
9822604 GOA
enables inositol diphosphate tetrakisphosphate diphosphatase activity IMP
IMP: Inferred from mutant phenotype
10585413 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
19585659 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
34788624 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
34788624 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA decapping IDA
IDA: Inferred from direct assay
32727897 GOA
involved in RNA decapping IMP
IMP: Inferred from mutant phenotype
26932476 GOA
involved in diadenosine hexaphosphate catabolic process IDA
IDA: Inferred from direct assay
34788624 GOA
involved in diphosphoinositol polyphosphate catabolic process IDA
IDA: Inferred from direct assay
10585413 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
34788624 GOA
located in nucleus IDA
IDA: Inferred from direct assay
34788624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT3 Protein Structure

NUDIX

NUDIX: NUDIX domain (20 - 134)

  • 0
  • 100
  • 172 a.a.
Protein Preferred Names Protein Names

diphosphoinositol polyphosphate phosphohydrolase 1

  • diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1

NUDT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUDT3 O95989 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
NUDT3 O95989 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
NUDT3 O95989 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09671 NUDT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUDT3 RGD RGD:1310183
Bos taurus NUDT3 VGNC VGNC:32338
Mus musculus NUDT3 MGD MGI:1928484
Macaca mulatta NUDT3 VGNC VGNC:75551
Canis familiaris NUDT3 VGNC VGNC:57226
Others NUDT3 NCBI