BAZ2A - bromodomain adjacent to zinc finger domain 2A Gene

Also Known as TIP5; WALp3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11176

About BAZ2A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,595,596-56,638,318 (from NCBI)

This gene has 17 transcripts (splice variants), 216 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 26.6), placenta (RPKM 20.1) and 25 other tissues.

Summary

Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation; histone deacetylation; and negative regulation of macromolecule metabolic process. Predicted to act upstream of or within chromatin organization and histone modification. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

BAZ2A Products (3)

mRNA Protein Name
NM_001300905.2 NP_001287834.1 bromodomain adjacent to zinc finger domain protein 2A isoform 2
NM_001351156.2 NP_001338085.1 bromodomain adjacent to zinc finger domain protein 2A isoform 3
NM_013449.4 NP_038477.2 bromodomain adjacent to zinc finger domain protein 2A isoform 1

BAZ2A Protein Structure

MBD

MBD: Methyl-CpG binding domain (548 - 617)

DDT

DDT: DDT domain (849 - 910)

WHIM1

WHIM1: WSTF, HB1, Itc1p, MBD9 motif 1 (952 - 997)

(1439 - 1473)

PHD

PHD: PHD-finger (1679 - 1724)

Bromodomain

Bromodomain: Bromodomain (1802 - 1881)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1905 a.a.
Protein Preferred Names Protein Names

bromodomain adjacent to zinc finger domain protein 2A

  • TTF-I interacting peptide 5

BAZ2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
BAZ2A Q9UIF9 Ttf1 Mus musculus Q62187
Y2H
11532953
Intra
BAZ2A Q9UIF9 NCK1 Homo sapiens P16333
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Spondylopathy

  • Inflammatory Spondylopathies In Disease Classified Elsewhere

  • Inflammatory Spondylopathies In Disease Ec

  • Inflammatory Spondylopathy In Disease Classified Elsewhere

  • Spondylitis
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 2

  • SRTD2

  • Atd2

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15658 GSK2801 99.86% Unkown
HY-19336 BAZ2-ICR Inhibitor 99.80% Unkown
HY-77826 4-Chloro-N-methylpicolinamide Inhibitor 99.89% Unkown
HY-107477 GSK8573 99.53% Unkown
HY-168448 dBAZ2 Degrader / Unkown
HY-168449 BAZ2A/B ligand 1 / Unkown
HY-168453 dBAZ2B Degrader / Unkown
HY-RS01379 BAZ2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18165 Baz2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24639 Baz2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BAZ2A VGNC VGNC:69154
Macaca mulatta BAZ2A VGNC VGNC:70232
Mus musculus BAZ2A MGD MGI:2151152
Rattus norvegicus BAZ2A RGD RGD:1305037
Bos taurus BAZ2A VGNC VGNC:26430
Canis familiaris BAZ2A VGNC VGNC:38391
Others BAZ2A NCBI