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Cat. No.: HY-W700258

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4-Chloro-N-methylpicolinamide-d₃

Name: 4-Chloro-N-methylpicolinamide-d3
Brand: MedChemExpress
SKU: HY-W700258
Price: 161.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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4-Chloro-N-methylpicolinamide-d₃ is the deuterated-labeled 4-Chloro-N-methylpicolinamide (HY-77826). 4-Chloro-N-methylpicolinamide (Compound 3) is a BAZ2A bromodomain inhibitor with a K_d of >500 μM. 4-Chloro-N-methylpicolinamide forms a weak hydrogen bond with the carbonyl oxygen of Pro1817. 4-Chloro-N-methylpicolinamide can be used in the research of invasive prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1189858-48-7
Formula: C₇H₄D₃ClN₂O
Molecular Weight:173.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

4-Chloro-N-methylpicolinamide-d₃ Chemical Structure

CAS No.: 1189858-48-7

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Description

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In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1189858-48-7
Unlabeled CAS 220000-87-3
Molecular Weight 173.61
Formula C₇H₄D₃ClN₂O
SMILES

ClC1=CC=NC(C(NC([2H])([2H])[2H])=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Spiliotopoulos D, et al. Discovery of BAZ2A bromodomain ligands. Eur J Med Chem. 2017 Oct 20;139:564-572. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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4-Chloro-N-methylpicolinamide-d3

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