PADI2 - peptidyl arginine deiminase 2 Gene

Also Known as PAD2; PDI2; PAD-H19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11240

About PADI2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,066,761-17,119,451 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 4 paralogues. Biased expression in colon (RPKM 47.2), brain (RPKM 33.8) and 6 other tissues.

Summary

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four Other paralogous genes. [provided by RefSeq, Jul 2008]

PADI2 Products (1)

mRNA Protein Name
NM_007365.3 NP_031391.2 protein-arginine deiminase type-2

PADI2 Protein Structure

PAD_N

PAD_N: Protein-arginine deiminase (PAD) N-terminal domain (1 - 114)

PAD_M

PAD_M: Protein-arginine deiminase (PAD) middle domain (116 - 274)

PAD

PAD: Protein-arginine deiminase (PAD) (280 - 665)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
Protein Preferred Names Protein Names

protein-arginine deiminase type-2

  • peptidyl arginine deiminase, type II

Recombinant PADI2 Proteins

Cat. No. Product Name Accession Purity
HY-P78738 PADI2 Protein, Human (HEK293, His) Q9Y2J8-1 (M1-P665) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Rheumatoid Arthritis Interstitial Lung Disease

  • Rheumatoid Lung
Felty Syndrome

  • Felty'S Syndrome

  • Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia

  • Familial Felty'S Syndrome

  • Rheumatoid Arthritis, Splenomegaly And Neutropenia

  • Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome

  • Feltys Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09961 PADI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18831 Padi2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25322 Padi2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PADI2 VGNC VGNC:75644
Rattus norvegicus PADI2 RGD RGD:3288
Canis familiaris PADI2 VGNC VGNC:44235
Mus musculus PADI2 MGD MGI:1338892
Felis catus PADI2 VGNC VGNC:64022
Bos taurus PADI2 VGNC VGNC:32546
Others PADI2 NCBI