PADI2 - peptidyl arginine deiminase 2 Gene

Homo sapiens

Also known as PAD2; PDI2; PAD-H19

Gene ID: 11240 | Gene type: protein coding

About PADI2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,066,761-17,119,451 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 4 paralogues. Biased expression in colon (RPKM 47.2), brain (RPKM 33.8) and 6 other tissues.

Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II Enzyme is the most widely expressed family member. Known substrates for this Enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This Enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI2 Products(1)

mRNA	Protein	Name
NM_007365.3	NP_031391.2	protein-arginine deiminase type-2

PADI2 Protein Structure

PAD_N

PAD_M

PAD

0
200
400
600
665 a.a.

Protein Preferred Names

Protein Names

protein-arginine deiminase type-2

peptidyl arginine deiminase, type II

Recombinant PADI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78738	PADI2 Protein, Human (HEK293, His)	Q9Y2J8-1 (M1-P665)	≥95%
HY-P700602	PADI2 Protein, Human (HEK293, N-His, C-Myc)	Q9Y2J8 (M1-P665)	≥95%

Related Diseases

Diseases

Alias

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Felty Syndrome

Felty'S Syndrome	Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia
Familial Felty'S Syndrome	Rheumatoid Arthritis, Splenomegaly And Neutropenia
Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome	Feltys Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09961	PADI2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PADI2	VGNC	VGNC:75644
Rattus norvegicus	PADI2	RGD	RGD:3288
Canis familiaris	PADI2	VGNC	VGNC:44235
Mus musculus	PADI2	MGD	MGI:1338892
Felis catus	PADI2	VGNC	VGNC:64022
Bos taurus	PADI2	VGNC	VGNC:32546
Others	PADI2	NCBI

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