SLC6A14 - solute carrier family 6 member 14 Gene
Also Known as BMIQ11
Species: Homo sapiens
About SLC6A14
This gene has 2 transcripts (splice variants), 30 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 8.9), salivary gland (RPKM 4.7) and 7 other tissues.
Summary
This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic Amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]
SLC6A14 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_007231.5 | NP_009162.1 | sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables (R)-carnitine transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
17855766 | GOA |
| enables alanine transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
19074966 | GOA |
| enables aromatic amino acid transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
10446133 | GOA |
| enables beta-alanine transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
18599538 | GOA |
| enables branched-chain amino acid:sodium symporter activity |
IDA
IDA: Inferred from direct assay
|
10446133 | GOA |
| enables neutral, basic amino acid:sodium:chloride symporter activity |
IDA
IDA: Inferred from direct assay
|
10446133 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in (R)-carnitine transmembrane transport |
IDA
IDA: Inferred from direct assay
|
17855766 | GOA |
| involved in alanine transport |
IDA
IDA: Inferred from direct assay
|
19074966 | GOA |
| involved in amino acid import across plasma membrane |
IDA
IDA: Inferred from direct assay
|
10446133 | GOA |
| involved in beta-alanine transport |
IDA
IDA: Inferred from direct assay
|
18599538 | GOA |
| involved in response to toxic substance |
IDA
IDA: Inferred from direct assay
|
17575980 | GOA |
SLC6A14 Protein Structure
SNF: Sodium:neurotransmitter symporter family (36 - 587)
- 0
- 100
- 200
- 300
- 400
- 500
- 600
- 642 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Body Mass Index Quantitative Trait Locus 11 |
|
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| Cystic Fibrosis |
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| Ileus |
|
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| Hartnup Disorder |
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| Estrogen-Receptor Positive Breast Cancer |
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| Hyperekplexia |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | SLC6A14 | MGD | MGI:1890216 |
| Rattus norvegicus | SLC6A14 | RGD | RGD:1561810 |
| Bos taurus | SLC6A14 | VGNC | VGNC:34917 |
| Macaca mulatta | SLC6A14 | VGNC | VGNC:77617 |
| Canis familiaris | SLC6A14 | VGNC | VGNC:46457 |
| Others | SLC6A14 | NCBI |