SCRG1 - stimulator of chondrogenesis 1 Gene

Also Known as SCRG-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11341

About SCRG1

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,384,701-173,519,144 (from NCBI)

This gene has 2 transcripts (splice variants) and 142 orthologues. Biased expression in brain (RPKM 46.0), testis (RPKM 30.3) and 3 other tissues.

Summary

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

SCRG1 Products (2)

mRNA	Protein	Name
NM_001329597.2	NP_001316526.1	scrapie-responsive protein 1 precursor
NM_007281.4	NP_009212.1	scrapie-responsive protein 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRG1 Protein Structure

SCRG1

0
98 a.a.

Protein Preferred Names	Protein Names
scrapie-responsive protein 1	scrapie responsive gene 1

SCRG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCRG1	O75711	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SCRG1	O75711	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SCRG1	O75711	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SCRG1	O75711	MANBAL	Homo sapiens	Q9NQG1	Validated Y2H	32296183
Intra	SCRG1	O75711	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	SCRG1	O75711	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	SCRG1	O75711	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	25416956
Intra	SCRG1	O75711	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	25416956
Intra	SCRG1	O75711	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SCRG1	O75711	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	SCRG1	O75711	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Scrapie

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12561	SCRG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22798	Scrg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29312	Scrg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SCRG1	VGNC	VGNC:50423
Mus musculus	SCRG1	MGD	MGI:1328308
Felis catus	SCRG1	VGNC	VGNC:64934
Bos taurus	SCRG1	VGNC	VGNC:34364
Rattus norvegicus	SCRG1	RGD	RGD:68377
Others	SCRG1	NCBI