MGLL - monoglyceride lipase Gene

Also Known as MGL; HUK5; MAGL; HU-K5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 11343

About MGLL

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,689,066-127,823,185 (from NCBI)

This gene has 13 transcripts (splice variants) and 209 orthologues. Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues.

Summary

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free Fatty Acids and glycerol. The encoded protein plays a critical role in several physiological processes including Pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in Cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

MGLL Products (10)

mRNA	Protein	Name
NM_001003794.3	NP_001003794.1	monoglyceride lipase isoform 2
NM_001256585.2	NP_001243514.1	monoglyceride lipase isoform 3
NM_001388312.1	NP_001375241.1	monoglyceride lipase isoform 4
NM_001388313.1	NP_001375242.1	monoglyceride lipase isoform 5
NM_001388314.1	NP_001375243.1	monoglyceride lipase isoform 6
NM_001388315.1	NP_001375244.1	monoglyceride lipase isoform 7
NM_001388316.1	NP_001375245.1	monoglyceride lipase isoform 8
NM_001388317.1	NP_001375246.1	monoglyceride lipase isoform 9
NM_001388318.1	NP_001375247.1	monoglyceride lipase isoform 9
NM_007283.7	NP_009214.1	monoglyceride lipase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	22969151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28298427	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19957260	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	22969151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGLL Protein Structure

Abhydrolase_6

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
monoglyceride lipase	lysophospholipase homolog

MGLL Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MGLL	Q99685	ADRB2	Homo sapiens	P07550	Anti Bait CoIP	28298427
Intra	MGLL	Q99685	ADRB2	Homo sapiens	P07550	Ub Reconstruction	28298427
Intra	MGLL	Q99685	HPCAL1	Homo sapiens	P37235	Anti Tag CoIP	28514442
Intra	MGLL	Q99685	HPCAL1	Homo sapiens	P37235	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

MGLL 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83201	Monoacylglycerol Lipase Antibody (YA2946)	WB	Human

関連疾患

Diseases	Alias
Hallucinogen Dependence	Hallucinogen Addiction
Cannabis Dependence	Marijuana Abuse Cannabinoid Addiction Cannabinoid Dependence Cannabis Addiction
Cannabis Abuse	Marijuana Abuse
Chanarin-Dorfman Syndrome	Neutral Lipid Storage Disease CDS Neutral Lipid Storage Disease With Ichthyosis Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation Triglyceride Storage Disease With Ichthyosis Nlsdi Ichthyotic Neutral Lipid Storage Disease Dorfman-Chanarin Syndrome Dcs Chanarin-Dorfman Disease Ichthyosiform Erythroderma With Leukocyte Vacuolation Lipidosis With Triglyceride Storage Disease Disorder Of Cornification 12 Dorfman Chanarin Syndrome Neutral Lipid Storage Disease With Ichthyotic Dorfman-Chanarin Disease
Uvulitis	Acute Uvulitis
Pain Agnosia	Analgesia
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-18540	KT109	Inhibitor	99.86%	Unkown
HY-124576	ABD-1970	Inhibitor	/	Unkown
HY-RS08409	MGLL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16868	Mgll Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23309	Mgll Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24917	Clec10a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	MGLL	MGD	MGI:1346042
Canis familiaris	MGLL	VGNC	VGNC:54327
Felis catus	MGLL	VGNC	VGNC:63489
Macaca mulatta	MGLL	VGNC	VGNC:74523
Bos taurus	MGLL	VGNC	VGNC:54454
Rattus norvegicus	MGLL	RGD	RGD:71039
Others	MGLL	NCBI