MGLL - monoglyceride lipase Gene

Also Known as MGL; HUK5; MAGL; HU-K5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11343

About MGLL

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,689,066-127,823,185 (from NCBI)

This gene has 13 transcripts (splice variants) and 209 orthologues. Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues.

Summary

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in Cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

MGLL Products (10)

mRNA Protein Name
NM_001003794.3 NP_001003794.1 monoglyceride lipase isoform 2
NM_001256585.2 NP_001243514.1 monoglyceride lipase isoform 3
NM_001388312.1 NP_001375241.1 monoglyceride lipase isoform 4
NM_001388313.1 NP_001375242.1 monoglyceride lipase isoform 5
NM_001388314.1 NP_001375243.1 monoglyceride lipase isoform 6
NM_001388315.1 NP_001375244.1 monoglyceride lipase isoform 7
NM_001388316.1 NP_001375245.1 monoglyceride lipase isoform 8
NM_001388317.1 NP_001375246.1 monoglyceride lipase isoform 9
NM_001388318.1 NP_001375247.1 monoglyceride lipase isoform 9
NM_007283.7 NP_009214.1 monoglyceride lipase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
22969151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28298427 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19957260 GOA
Biological Process GO Annotation Evidence References Source
involved in acylglycerol catabolic process IDA
IDA: Inferred from direct assay
22969151 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGLL Protein Structure

Abhydrolase_6

Abhydrolase_6: Alpha/beta hydrolase family (46 - 280)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

monoglyceride lipase

  • lysophospholipase homolog

MGLL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MGLL Q99685 ADRB2 Homo sapiens P07550
Anti Bait CoIP
28298427
Intra
MGLL Q99685 ADRB2 Homo sapiens P07550
Ub Reconstruction
28298427
Intra
MGLL Q99685 HPCAL1 Homo sapiens P37235
Anti Tag CoIP
28514442
Intra
MGLL Q99685 HPCAL1 Homo sapiens P37235
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

MGLL Antibodies

Cat. No. Product Name Application Reactivity
HY-P83201 Monoacylglycerol Lipase Antibody (YA2946) WB Human

Related Diseases

Diseases Alias
Hallucinogen Dependence

  • Hallucinogen Addiction
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Cannabis Abuse

  • Marijuana Abuse
Chanarin-Dorfman Syndrome

  • Neutral Lipid Storage Disease

  • CDS

  • Neutral Lipid Storage Disease With Ichthyosis

  • Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

  • Triglyceride Storage Disease With Ichthyosis

  • Nlsdi

  • Ichthyotic Neutral Lipid Storage Disease

  • Dorfman-Chanarin Syndrome

  • Dcs

  • Chanarin-Dorfman Disease

  • Ichthyosiform Erythroderma With Leukocyte Vacuolation

  • Lipidosis With Triglyceride Storage Disease

  • Disorder Of Cornification 12

  • Dorfman Chanarin Syndrome

  • Neutral Lipid Storage Disease With Ichthyotic

  • Dorfman-Chanarin Disease
Uvulitis

  • Acute Uvulitis
Pain Agnosia

  • Analgesia
Gilles De La Tourette Syndrome

  • Tourette Syndrome

  • Tourette Disorder

  • GTS

  • Ts

  • Gilles De La Tourette'S Syndrome

  • Motor-Verbal Tic Disorder

  • Guinon'S Disease

  • Psychogenic Tics

  • Tourette'S Syndrome

  • Chronic Motor And Vocal Tic Disorder

  • Td

  • Tourette'S Disease

  • Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

  • Combined Vocal And Multiple Motor Tic Disorder

  • Tic De La Tourette
Lennox-Gastaut Syndrome

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18540 KT109 Inhibitor 99.86% Unkown
HY-124576 ABD-1970 Inhibitor / Unkown
HY-RS08409 MGLL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16868 Mgll Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23309 Mgll Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24917 Clec10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MGLL MGD MGI:1346042
Canis familiaris MGLL VGNC VGNC:54327
Felis catus MGLL VGNC VGNC:63489
Macaca mulatta MGLL VGNC VGNC:74523
Bos taurus MGLL VGNC VGNC:54454
Rattus norvegicus MGLL RGD RGD:71039
Others MGLL NCBI