MGLL - monoglyceride lipase Gene

Homo sapiens

Also known as MGL; HUK5; MAGL; HU-K5

Gene ID: 11343 | Gene type: protein coding

About MGLL

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,689,066-127,823,185 (from NCBI)

This gene has 13 transcripts (splice variants) and 209 orthologues. Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues.

Summary

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in Cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

MGLL Products(10)

mRNA	Protein	Name
NM_001003794.3	NP_001003794.1	monoglyceride lipase isoform 2
NM_001256585.2	NP_001243514.1	monoglyceride lipase isoform 3
NM_001388312.1	NP_001375241.1	monoglyceride lipase isoform 4
NM_001388313.1	NP_001375242.1	monoglyceride lipase isoform 5
NM_001388314.1	NP_001375243.1	monoglyceride lipase isoform 6
NM_001388315.1	NP_001375244.1	monoglyceride lipase isoform 7
NM_001388316.1	NP_001375245.1	monoglyceride lipase isoform 8
NM_001388317.1	NP_001375246.1	monoglyceride lipase isoform 9
NM_001388318.1	NP_001375247.1	monoglyceride lipase isoform 9
NM_007283.7	NP_009214.1	monoglyceride lipase isoform 1

MGLL Protein Structure

Abhydrolase_6

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

monoglyceride lipase

lysophospholipase homolog

Related Diseases

Diseases

Alias

Hallucinogen Dependence

Hallucinogen Addiction

Cannabis Dependence

Marijuana Abuse	Cannabinoid Addiction
Cannabinoid Dependence	Cannabis Addiction

Cannabis Abuse

Marijuana Abuse

Chanarin-Dorfman Syndrome

Neutral Lipid Storage Disease	CDS
Neutral Lipid Storage Disease With Ichthyosis	Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation
Triglyceride Storage Disease With Ichthyosis	Nlsdi
Ichthyotic Neutral Lipid Storage Disease	Dorfman-Chanarin Syndrome
Dcs	Chanarin-Dorfman Disease
Ichthyosiform Erythroderma With Leukocyte Vacuolation	Lipidosis With Triglyceride Storage Disease
Disorder Of Cornification 12	Dorfman Chanarin Syndrome
Neutral Lipid Storage Disease With Ichthyotic	Dorfman-Chanarin Disease

Uvulitis

Acute Uvulitis

Pain Agnosia

Analgesia

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.82%	Unkown
HY-RS08409	MGLL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MGLL	MGD	MGI:1346042
Canis familiaris	MGLL	VGNC	VGNC:54327
Felis catus	MGLL	VGNC	VGNC:63489
Macaca mulatta	MGLL	VGNC	VGNC:74523
Bos taurus	MGLL	VGNC	VGNC:54454
Rattus norvegicus	MGLL	RGD	RGD:71039
Others	MGLL	NCBI

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