UCN3 - urocortin 3 Gene

Also Known as SCP; SPC; UCNIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114131

About UCN3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,364,966-5,374,692 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 1 paralogue. Biased expression in duodenum (RPKM 4.8), small intestine (RPKM 3.4) and 8 other tissues.

Summary

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate Insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

UCN3 Products (1)

mRNA Protein Name
NM_053049.4 NP_444277.2 urocortin-3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables corticotropin-releasing hormone receptor binding IPI
IPI: Inferred from physical interaction
11329063 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20966082 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11329063 GOA
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
11329063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCN3 Protein Structure

(120 - 157)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

urocortin-3

  • prepro-urocortin 3

Related Diseases

Diseases Alias
Mixed Sleep Apnea

  • Complex Sleep Apnea

  • Sleep Apnea, Mixed Central And Obstructive
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1858A Urocortin III, mouse TFA Activator 98.06% Unkown
HY-P1858 Urocortin III, mouse Activator 98.29% Unkown
HY-RS15409 UCN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21451 Ucn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27969 Ucn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UCN3 VGNC VGNC:79090
Bos taurus UCN3 VGNC VGNC:36639
Mus musculus UCN3 MGD MGI:1932970
Canis familiaris UCN3 VGNC VGNC:48110
Felis catus UCN3 VGNC VGNC:82339
Rattus norvegicus UCN3 RGD RGD:1562213
Others UCN3 NCBI