Trpv6 - transient receptor potential cation channel, subfamily V, member 6 Gene

Also Known as CaT1; Ecac2; Otrpc3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114246

Summary

Enables Calcium Channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and protein homotetramerization. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpv6 Products (1)

mRNA Protein Name
NM_053686.2 NP_446138.2 transient receptor potential cation channel subfamily V member 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
10428857 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
27296226 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion import IDA
IDA: Inferred from direct assay
10875938 RGD
involved in calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
10428857 RGD
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
10428857 RGD
involved in protein homotetramerization IPI
IPI: Inferred from physical interaction
27296226 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily V member 6

  • calcium transport protein 1

  • epithelial apical membrane calcium transporter/channel CaT1

  • epithelial calcium channel 2

  • osmosensitive transient receptor potential channel 3

  • transient receptor potential cation channel, subfamily 5, member 6

Trpv6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Trpv6 Q9R186 Trpv6 Rattus norvegicus Q9R186
GMS
27296226
Intra
Trpv6 Q9R186 Trpv6 Rattus norvegicus Q9R186
X-Ray Diffraction
27296226
Intra
Trpv6 Q9R186 Trpv6 Rattus norvegicus Q9R186
Crosslink
27296226
Intra
Trpv6 Q9R186 PTPN1 Homo sapiens P18031
Y2H
17197020
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P1651 SOR-C13 Antagonist 99.12% Phase 1
HY-P1651A SOR-C13 TFA Antagonist 99.32% Phase 1
HY-P1651B SOR-C13 acetate Antagonist 99.11% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157574 TRPV6-IN-1 Inhibitor 99.1% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpv6 NCBI NCBI:55503