Bik - BCL2-interacting killer Gene

Also Known as Blk; Biklk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114496

Summary

Enables BH domain binding activity. Predicted to be involved in apoptotic mitochondrial changes; male gonad development; and positive regulation of cellular component organization. Predicted to act upstream of or within spermatogenesis. Predicted to be located in mitochondrial envelope. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate Cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Apr 2022]

Bik Products (1)

mRNA Protein Name
NM_053704.2 NP_446156.1 bcl-2-interacting killer

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl-2-interacting killer

  • BCL2-interacting killer (apoptosis-inducing)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-50868 Bafetinib 99.18% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5341 Bik BH3 99.05% Unkown
HY-E70861 SIK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS01503 BIK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17788 Bik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24255 Bik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bik NCBI NCBI:638