GPR146 - G protein-coupled receptor 146 Gene

Also Known as PGR8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115330

About GPR146

This gene has 5 transcripts (splice variants), 65 orthologues and 7 paralogues. Broad expression in fat (RPKM 14.9), lung (RPKM 4.6) and 18 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR146 Products (3)

mRNA Protein Name
NM_001303473.2 NP_001290402.1 probable G-protein coupled receptor 146
NM_001303474.2 NP_001290403.1 probable G-protein coupled receptor 146
NM_138445.4 NP_612454.1 probable G-protein coupled receptor 146

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
38503280 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
38503280 GOA
involved in regulation of cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
38503280 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
38503280 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23759446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR146 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (45 - 296)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 146

  • G-protein coupled receptor PGR8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS29469 GPR146 Domestic cattle Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05666 GPR146 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21135 Gpr146 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27653 Gpr146 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR146 VGNC VGNC:62677
Macaca mulatta GPR146 VGNC VGNC:72979
Canis familiaris GPR146 VGNC VGNC:41402
Rattus norvegicus GPR146 RGD RGD:1560731
Mus musculus GPR146 MGD MGI:1933113
Bos taurus GPR146 VGNC VGNC:29555
Others GPR146 NCBI