2. Gene
  3. ARHGEF25 - Rho guanine nucleotide exchange factor 25 Gene

ARHGEF25 - Rho guanine nucleotide exchange factor 25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GEFT; p63RhoGEF

Gene ID: 115557 | Gene type: protein coding

About ARHGEF25

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,610,116-57,617,245 (from NCBI)

This gene has 7 transcripts (splice variants), 192 orthologues and 22 paralogues. Broad expression in endometrium (RPKM 29.1), prostate (RPKM 19.9) and 22 other tissues.

Summary

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

ARHGEF25 Products(3)

mRNA Protein Name
NM_001111270.3 NP_001104740.2 rho guanine nucleotide exchange factor 25 isoform 3
NM_001347933.2 NP_001334862.2 rho guanine nucleotide exchange factor 25 isoform 4
NM_182947.4 NP_891992.3 rho guanine nucleotide exchange factor 25 isoform 1

ARHGEF25 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (164 - 335)

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  • 580 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 25

RAC/CDC42 exchange factor

Related Diseases

Diseases Alias
Moyamoya Angiopathy
Parameningeal Embryonal Rhabdomyosarcoma
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Rhinitis, Atrophic

Ozena

Rhinitis Sicca

Dry Rhinitis

Ozaena
Dyschromatosis Universalis Hereditaria

Duh
Rhabdomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00955 ARHGEF25 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF25 VGNC VGNC:38081
Macaca mulatta ARHGEF25 VGNC VGNC:69929
Rattus norvegicus ARHGEF25 RGD RGD:735210
Mus musculus ARHGEF25 MGD MGI:1277173
Bos taurus ARHGEF25 VGNC VGNC:26112