TRMT61A - tRNA methyltransferase 61A Gene

Also Known as GCD14; TRM61; Gcd14p; hTRM61; C14orf172

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115708

About TRMT61A

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues.

Summary

Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRMT61A Products (1)

mRNA Protein Name
NM_152307.3 NP_689520.2 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA (adenine-N1-)-methyltransferase activity IDA
IDA: Inferred from direct assay
29072297 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16043508 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
29072297 GOA
Cellular Component GO Annotation Evidence References Source
part of tRNA (m1A) methyltransferase complex IPI
IPI: Inferred from physical interaction
26470919 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT61A Protein Structure

GCD14

GCD14: tRNA methyltransferase complex GCD14 subunit (64 - 286)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

  • mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A

TRMT61A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRMT61A Q96FX7 TRMT6 Homo sapiens Q9UJA5
Anti Tag CoIP
28514442
Intra
TRMT61A Q96FX7 TRMT6 Homo sapiens Q9UJA5
Anti Tag CoIP
16043508
Intra
TRMT61A Q96FX7 TRMT6 Homo sapiens Q9UJA5
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15095 TRMT61A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRMT61A RGD RGD:1359191
Felis catus TRMT61A VGNC VGNC:66575
Mus musculus TRMT61A MGD MGI:2443487
Bos taurus TRMT61A VGNC VGNC:36375
Canis familiaris TRMT61A VGNC VGNC:47860
Macaca mulatta TRMT61A VGNC VGNC:79412
Others TRMT61A NCBI