TRMT6 - tRNA methyltransferase 6 non-catalytic subunit Gene

Also Known as GCD10; CGI-09; Gcd10p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51605

About TRMT6

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRMT6 Products (2)

mRNA Protein Name
NM_001281467.2 NP_001268396.1 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2
NM_015939.5 NP_057023.2 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16043508 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
29072297 GOA
Cellular Component GO Annotation Evidence References Source
part of tRNA (m1A) methyltransferase complex IPI
IPI: Inferred from physical interaction
26470919 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT6 Protein Structure

Gcd10p

Gcd10p: Gcd10p family (18 - 289)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

  • mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6

TRMT6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRMT6 Q9UJA5 PPIA Homo sapiens P62937-2
Validated Y2H
32814053
Intra
TRMT6 Q9UJA5 PPIA Homo sapiens P62937-2
Y2H Array
32814053
Intra
TRMT6 Q9UJA5 PPIA Homo sapiens P62937-2
Y2H Pooling
32814053
Intra
TRMT6 Q9UJA5 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
TRMT6 Q9UJA5 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
TRMT6 Q9UJA5 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
TRMT6 Q9UJA5 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
TRMT6 Q9UJA5 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
TRMT6 Q9UJA5 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
TRMT6 Q9UJA5 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
TRMT6 Q9UJA5 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
TRMT6 Q9UJA5 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
TRMT6 Q9UJA5 TRMT61A Homo sapiens Q96FX7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15094 TRMT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRMT6 VGNC VGNC:66574
Rattus norvegicus TRMT6 RGD RGD:1308877
Bos taurus TRMT6 VGNC VGNC:36374
Canis familiaris TRMT6 VGNC VGNC:54738
Macaca mulatta TRMT6 VGNC VGNC:79294
Mus musculus TRMT6 MGD MGI:1914176
Others TRMT6 NCBI