Npr2 - natriuretic peptide receptor 2 Gene

Also Known as GC-B; NPR-B

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116564

Summary

Enables peptide hormone binding activity. Involved in cGMP-mediated signaling and positive regulation of cGMP-mediated signaling. Located in plasma membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Npr2 Products (1)

mRNA Protein Name
NM_053838.1 NP_446290.1 atrial natriuretic peptide receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peptide hormone binding IMP
IMP: Inferred from mutant phenotype
16537417 RGD
Biological Process GO Annotation Evidence References Source
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
14691198 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: Inferred from direct assay
7552344 RGD
involved in positive regulation of platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26410366 RGD
involved in wound healing IMP
IMP: Inferred from mutant phenotype
26410366 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrial natriuretic peptide receptor 2

  • ANP-B

  • ANPR-B

  • ANPRB

  • atrial natriuretic peptide B-type receptor

  • atrial natriuretic peptide receptor B

  • atrial natriuretic peptide receptor type B

  • guanylate cyclase B

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3503A Vosoritide acetate Inhibitor 99.96% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09498 NPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09500 NPRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21394 Npr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27913 Npr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npr2 NCBI NCBI:4882