Tnc - tenascin C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116640

Summary

Predicted to enable syndecan binding activity. Involved in several processes, including animal organ morphogenesis; cellular response to lipid; and cellular response to prostaglandin D stimulus. Located in extracellular matrix. Used to study pulmonary hypertension. Biomarker of cholangiocarcinoma; high grade glioma; myocardial infarction; polycystic kidney disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; and autosomal dominant nonsyndromic deafness 56. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]

Tnc Products (1)

mRNA Protein Name
NM_053861.2 NP_446313.2 tenascin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in bud outgrowth involved in lung branching IMP
IMP: Inferred from mutant phenotype
16928692 RGD
involved in cellular response to prostaglandin D stimulus IEP
IEP: Inferred from expression pattern
10502285 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
10502285 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
10502285 RGD
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
7519614 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
19403822 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
12971948 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15565633 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
12060805 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19541731 RGD
Cellular Component GO Annotation Evidence References Source
is active in extracellular matrix of synaptic cleft IDA
IDA: Inferred from direct assay
21734302 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21734302 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tenascin

  • Tn-C AD1

  • tenascin-C AD1 domain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14783 TNC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17263 Tnc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148543 FC-99 Inhibitor / Unkown
HY-RS14848 TNNC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19041 Tnnc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23717 Tnc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnc NCBI NCBI:3371