2. Gene
  3. TNC - tenascin C Gene

TNC - tenascin C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225

Gene ID: 3371 | Gene type: protein coding

About TNC

Cytogenetic location: 9q33.1 Genomic coordinates (GRCh38): 9:115,019,575-115,118,157 (from NCBI)

This gene has 15 transcripts (splice variants), 200 orthologues, 25 paralogues and is associated with 90 phenotypes. Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues.

Summary

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC Products(2)

mRNA Protein Name
NM_001410991.1 NP_001397920.1 tenascin isoform 2 precursor
NM_002160.4 NP_002151.2 tenascin isoform 1 precursor

TNC Protein Structure

hEGF

hEGF: Human growth factor-like EGF (204 - 216)

EGF_2

EGF_2: EGF-like domain (221 - 247)

EGF_2

EGF_2: EGF-like domain (252 - 279)

hEGF

hEGF: Human growth factor-like EGF (298 - 310)

EGF_2

EGF_2: EGF-like domain (377 - 403)

EGF_2

EGF_2: EGF-like domain (408 - 434)

EGF_2

EGF_2: EGF-like domain (470 - 496)

EGF_2

EGF_2: EGF-like domain (501 - 527)

EGF_2

EGF_2: EGF-like domain (532 - 558)

hEGF

hEGF: Human growth factor-like EGF (609 - 620)

fn3

fn3: Fibronectin type III domain (624 - 696)

fn3

fn3: Fibronectin type III domain (713 - 793)

fn3

fn3: Fibronectin type III domain (804 - 879)

fn3

fn3: Fibronectin type III domain (894 - 974)

fn3

fn3: Fibronectin type III domain (987 - 1062)

fn3

fn3: Fibronectin type III domain (1077 - 1150)

fn3

fn3: Fibronectin type III domain (1169 - 1241)

fn3

fn3: Fibronectin type III domain (1259 - 1327)

fn3

fn3: Fibronectin type III domain (1350 - 1422)

fn3

fn3: Fibronectin type III domain (1440 - 1507)

fn3

fn3: Fibronectin type III domain (1533 - 1605)

fn3

fn3: Fibronectin type III domain (1622 - 1696)

fn3

fn3: Fibronectin type III domain (1712 - 1787)

fn3

fn3: Fibronectin type III domain (1802 - 1873)

fn3

fn3: Fibronectin type III domain (1889 - 1960)

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (1981 - 2188)

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  • 2201 a.a.
Protein Preferred Names Protein Names

tenascin

GP 150-225

Recombinant TNC Proteins

Cat. No. Product Name Accession Purity
HY-P71691 TNC Protein, Human (His) P24821 (D1888-A2201) ≥95%
HY-P700833 Tenascin/Tnc protein, Human (HEK293, His) P24821-1 (G23-S621) ≥95%

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 56

DFNA56

Autosomal Dominant Nonsyndromic Deafness 56

Autosomal Dominant Deafness 56

Deafness, Autosomal Dominant, 56

Deafness, Autosomal Dominant, Type 56
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Bullous Keratopathy

Bk - [Bullous Keratopathy]
Acute Myocarditis
Glioma
Juvenile Pilocytic Astrocytoma
Cryptogenic Organizing Pneumonia

Bronchiolitis Obliterans Organizing Pneumonia

Boop

Constrictive Bronchiolitis

Cryptogenic Organizing Pneumonitis

Cop

Bronchiolitis Obliterans Organising Pneumonia

Cryptogenic Organising Pneumonia

Cryptogenic Organising Pneumonitis

Idiopathic Bronchiolitis Obliterans With Organising Pneumonia

Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia

Organizing Pneumonia

Idiopathic Boop

Idiopathic Bronchiolitis Obliterans Organizing Pneumonia

Organized Pneumonia
Tendinopathy
Tarsal Tunnel Syndrome

Neuropathy Of The Posterior Tibial Nerve And Its Branches

Posterior Tibial Nerve Neuralgia

Compression Of Posterior Tibial Nerve In Tarsal Tunnel
Tibial Neuropathy

Posterior Tibial Neuropathy
Dentinogenesis Imperfecta

Hereditary Opalescent Dentin

Dentinogenesis Imperfecta Without Osteogenesis Imperfecta

Dgi

Capdepont Teeth

Dgi Without Oi

Di

Non-Syndromic Dgi

Non-Syndromic Dentinogenesis Imperfecta

Opalescent Teeth Without Oi

Opalescent Teeth Without Osteogenesis Imperfecta

Opalescent Dentin
Interstitial Pneumonitis, Desquamative, Familial

Desquamative Interstitial Pneumonia

DIP

Pneumonitis, Desquamative Interstitial, Familial

Pneumonia, Desquamative Interstitial, Familial

Interstitial Lung Disease, Desquamative

Ild, Desquamative

Familial Desquamative Interstitial Pneumonitis

Rbild

Respiratory Bronchiolitis-Associated Interstitial Lung Disease

Respiratory Bronchiolitis Associated Interstitial Lung Disease
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Merkel Cell Carcinoma

Trabecular Adenocarcinoma

Cutaneous Neuroendocrine Carcinoma

Trabecular Carcinoma

Carcinoma, Merkel Cell

Merkel Cell Cancer

Merkle Tumors

Mcc

Carcinoma Merkel Cell
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis
Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders
Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease
Breast Disease

Breast Diseases
Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14783 TNC Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNC RGD RGD:621057
Bos taurus TNC VGNC VGNC:36152
Mus musculus TNC MGD MGI:101922
Macaca mulatta TNC VGNC VGNC:79960
Canis familiaris TNC VGNC VGNC:47646
Felis catus TNC VGNC VGNC:67678
Others TNC NCBI